{"id":"W324951808","doi":"10.1182/blood.v122.21.90.90","title":"Preliminary Evidence Of Anti Tumor Activity Of Selinexor (KPT-330) In a Phase I Trial Ofa First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Relapsed / Refractory Non Hodgkin’s Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ozmosis Research (Canada); Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Neutropenia; Tolerability; Medicine; Internal medicine; Pharmacodynamics; Gastroenterology; Febrile neutropenia; Adverse effect; Pharmacokinetics; Refractory (planetary science); Pharmacology; Toxicity; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009782498,0.0005741601,0.0009541838,0.0002026116,0.0001876032,0.0005182343,0.0003126236,0.0004712193,0.002565686],"category_scores_gemma":[0.0005474386,0.0002585171,0.0005471313,0.0001764168,0.000501009,0.0004171849,0.0001669632,0.001334513,0.0004070738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003216266,"about_ca_system_score_gemma":0.0004703005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003472241,"about_ca_topic_score_gemma":0.001362358,"domain_scores_codex":[0.9997925,0.0001172657,0.00001372903,0.00002422305,0.00001510644,0.0000371608],"domain_scores_gemma":[0.9995775,0.0001499253,0.00006612261,0.00002904874,0.00002403804,0.0001533462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5230058,0.03303491,0.02616703,0.001500081,0.001066837,0.0009111997,0.0007104637,0.003123787,0.2181422,0.0004130399,0.003728513,0.1881961],"study_design_scores_gemma":[0.1541343,0.7684065,0.04389541,0.0000703043,0.0006338539,0.0008800094,0.000156535,0.001513376,0.02483184,0.0001736949,0.005272853,0.00003138083],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968573,0.0007914294,0.0002928099,0.0001742309,0.00002492154,0.0003756356,0.0004095764,0.00004346992,0.001030515],"genre_scores_gemma":[0.9964679,0.0006178585,0.0004704054,0.0001901068,0.00004858675,0.0002837939,0.0007984124,0.00001045042,0.00111251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002565686,"threshold_uncertainty_score":0.008583069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006923298756439553,"score_gpt":0.222188814725335,"score_spread":0.2152655159688955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}