{"id":"W324951808","doi":"10.1182/blood.v122.21.90.90","title":"Preliminary Evidence Of Anti Tumor Activity Of Selinexor (KPT-330) In a Phase I Trial Ofa First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Relapsed / Refractory Non Hodgkin’s Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ozmosis Research (Canada); Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Neutropenia; Tolerability; Medicine; Internal medicine; Pharmacodynamics; Gastroenterology; Febrile neutropenia; Adverse effect; Pharmacokinetics; Refractory (planetary science); Pharmacology; Toxicity; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001703233,0.0001994186,0.0004342075,0.0001493466,0.00001966253,0.000006699849,0.0001205632,0.0001894601,0.000009680309],"category_scores_gemma":[0.000126313,0.0001789275,0.00005606312,0.0002402457,0.0001268454,0.00004266047,0.00008372819,0.0001073948,7.599863e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003239394,"about_ca_system_score_gemma":0.0006461904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007898237,"about_ca_topic_score_gemma":0.0002761511,"domain_scores_codex":[0.9986458,0.0000922595,0.0004548368,0.0003960133,0.0001943159,0.0002167381],"domain_scores_gemma":[0.9991117,0.00003421024,0.0003807955,0.0002856573,0.0001367282,0.00005088465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04674735,0.001857565,0.02836523,0.0003974804,0.00008370859,0.00001402837,0.000365374,0.00009518418,0.9182791,9.433373e-7,0.00009832808,0.003695694],"study_design_scores_gemma":[0.1274464,0.02751211,0.3669894,0.0007012725,0.0001075669,0.00001680861,0.0001145221,0.001275282,0.4754149,0.000006756905,0.00006856892,0.0003464454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988194,0.0001864621,0.000003912639,0.000005812671,0.00007020871,0.0008727479,0.00001095202,0.000004868496,0.00002566448],"genre_scores_gemma":[0.9996209,0.00007839129,0.0001397721,0.00001420572,0.00005930767,0.00003623508,0.00001311591,0.00002967638,0.00000837833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4428642,"threshold_uncertainty_score":0.7296453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006923298756439553,"score_gpt":0.222188814725335,"score_spread":0.2152655159688955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}