{"id":"W325483766","doi":"10.1371/journal.ppat.1004853","title":"Brucella abortus Induces the Premature Death of Human Neutrophils through the Action of Its Lipopolysaccharide","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Brucella: diagnosis, epidemiology, treatment","field":"Veterinary","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Consejo Nacional de Rectores; Institut National de la Santé et de la Recherche Médicale; Universidad de Costa Rica; Centre National de la Recherche Scientifique; Universidad de Navarra; Aix-Marseille Université; Fondation Méditerranée Infection","keywords":"Programmed cell death; Innate immune system; Biology; Caspase; Necroptosis; TLR4; Lipopolysaccharide; Proinflammatory cytokine; Pyroptosis; Immunology; Apoptosis; Cell biology; CD14; Respiratory burst; Neutrophil extracellular traps; Microbiology; Inflammation; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002850327,0.0003468901,0.0003086634,0.0001195956,0.0001039921,0.000170438,0.0001043697,0.000298088,0.001445443],"category_scores_gemma":[0.0001875179,0.0001291436,0.0002010436,0.00007173203,0.0001016389,0.0001046721,0.0002796705,0.0004847772,0.0003940231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000112107,"about_ca_system_score_gemma":0.0001256688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003309645,"about_ca_topic_score_gemma":0.0003308027,"domain_scores_codex":[0.9997266,0.0000920638,0.00002602169,0.00003038932,0.00005628993,0.00006874709],"domain_scores_gemma":[0.9999107,0.00001764227,0.00002026055,0.00001767183,0.00001342041,0.00002020648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005406108,0.0001353919,0.0006411237,0.00008240521,0.00001117764,0.0002985064,0.0000495762,0.00003461775,0.9950296,0.00007521442,0.000159757,0.00294198],"study_design_scores_gemma":[0.0001783778,0.00836125,0.04397826,0.00005698248,0.00004412181,0.002178457,0.000116989,0.001363212,0.937678,0.0001992533,0.005831454,0.0000135282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990971,0.004530352,0.001811363,0.0002051881,0.00008074919,0.00008417763,0.0002644237,0.00007446914,0.001978199],"genre_scores_gemma":[0.9964318,0.0008804753,0.0006709165,0.0001763485,0.00002390964,0.00006340213,0.0003332582,0.000005654873,0.001414194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001445443,"threshold_uncertainty_score":0.004835486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2640138242763703,"score_gpt":0.3872840674473202,"score_spread":0.1232702431709499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}