{"id":"W325483766","doi":"10.1371/journal.ppat.1004853","title":"Brucella abortus Induces the Premature Death of Human Neutrophils through the Action of Its Lipopolysaccharide","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Brucella: diagnosis, epidemiology, treatment","field":"Veterinary","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Consejo Nacional de Rectores; Institut National de la Santé et de la Recherche Médicale; Universidad de Costa Rica; Centre National de la Recherche Scientifique; Universidad de Navarra; Aix-Marseille Université; Fondation Méditerranée Infection","keywords":"Programmed cell death; Innate immune system; Biology; Caspase; Necroptosis; TLR4; Lipopolysaccharide; Proinflammatory cytokine; Pyroptosis; Immunology; Apoptosis; Cell biology; CD14; Respiratory burst; Neutrophil extracellular traps; Microbiology; Inflammation; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006192192,0.0003385939,0.0006041235,0.00006052283,0.0001978218,0.00001770272,0.000600443,0.0002966147,0.0000762097],"category_scores_gemma":[0.000432563,0.000192843,0.0002473546,0.0001842701,0.0002062784,0.0001356791,0.0001936902,0.0004016497,0.0000611809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000111948,"about_ca_system_score_gemma":0.00009242364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005027608,"about_ca_topic_score_gemma":0.000073296,"domain_scores_codex":[0.9972513,0.0007567795,0.0007215852,0.00043911,0.0004159005,0.000415357],"domain_scores_gemma":[0.9971468,0.0006882635,0.000717712,0.001065476,0.0002787429,0.0001029379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002426576,0.0009660723,0.01406067,0.0001707366,0.0006202132,0.00007104232,0.005720135,0.000126059,0.9682131,0.006904318,0.00247198,0.0004330048],"study_design_scores_gemma":[0.001708972,0.00337398,0.09104638,0.0004138195,0.001457207,0.0002594736,0.004143436,0.0001528511,0.8853955,0.008929516,0.002417406,0.0007014437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917043,0.003078137,0.000006565568,0.001578389,0.0003440512,0.0009046898,0.0001675849,0.00007748913,0.002138789],"genre_scores_gemma":[0.9981778,0.0005507212,0.0002852104,0.0003015171,0.0003347641,0.0001749067,0.00002385388,0.0000531357,0.00009812164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0828176,"threshold_uncertainty_score":0.786391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2640138242763703,"score_gpt":0.3872840674473202,"score_spread":0.1232702431709499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}