{"id":"W325888028","doi":"10.1016/j.jconrel.2015.05.278","title":"Microneedle patch delivery to the skin of virus-like particles containing heterologous M2e extracellular domains of influenza virus induces broad heterosubtypic cross-protection","year":2015,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity; University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Virology; Immunogenicity; Vaccination; Immunization; Influenza vaccine; Virus; Heterologous; Antigenicity; Reassortment; Virus-like particle; Influenza A virus; Antibody; Medicine; Immunology; Biology; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002905643,0.0003044836,0.001400822,0.0004190851,0.0001793572,0.00005615365,0.0003453025,0.0001915883,0.0000280317],"category_scores_gemma":[0.002779996,0.0001915498,0.000533499,0.000365718,0.0003872861,0.00027286,0.00014311,0.0007486079,0.0000225676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000209438,"about_ca_system_score_gemma":0.0004563933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000823195,"about_ca_topic_score_gemma":0.000149474,"domain_scores_codex":[0.9957244,0.0005969996,0.001791732,0.0002348392,0.001126116,0.0005258988],"domain_scores_gemma":[0.9953038,0.0004216787,0.001376849,0.0004445386,0.002006425,0.0004467548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0859924,0.0006535095,0.009892751,0.0001151538,0.001421371,0.000213531,0.004009506,0.003518906,0.8862925,0.00001235175,0.0004757364,0.00740225],"study_design_scores_gemma":[0.1365104,0.02176733,0.05273136,0.001085219,0.001573693,0.0006115816,0.005266153,0.003204777,0.7624201,0.0003535362,0.01374452,0.0007313162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847236,0.0126379,0.0006066794,0.0004708551,0.0002887113,0.001181844,0.00002430321,0.00001609895,0.00005002166],"genre_scores_gemma":[0.9981138,0.000256938,0.0003548566,0.0008049545,0.000313543,0.00004941902,8.467428e-7,0.00003462348,0.00007103771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1238724,"threshold_uncertainty_score":0.7811174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07241375669356342,"score_gpt":0.3470098247076733,"score_spread":0.2745960680141099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}