{"id":"W326971003","doi":"10.1007/s002399910029","title":"The Contributions of Replication Orientation, Gene Direction, and Signal Sequences to Base-Composition Asymmetries in Bacterial Genomes","year":2000,"lang":"en","type":"article","venue":"Journal of Molecular Evolution","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":185,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Codon usage bias; Genetics; Genome; Gene; Replication (statistics); DNA replication; GC-content; Bacterial genome size; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008121785,0.0002829881,0.0003671049,0.0005798822,0.0004642575,0.00118135,0.0003040757,0.0004622707,0.0008018379],"category_scores_gemma":[0.002930955,0.0005841851,0.000225461,0.0003193119,0.0006589788,0.000706408,0.0004073771,0.0008249525,0.0003987863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003446872,"about_ca_system_score_gemma":0.000457367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009667165,"about_ca_topic_score_gemma":0.001677192,"domain_scores_codex":[0.9996966,0.00008397504,0.00002316975,0.00005961438,0.00008567076,0.00005103053],"domain_scores_gemma":[0.997792,0.001167414,0.0003067983,0.0001335588,0.0003203835,0.0002798299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006677469,0.00003383171,0.0188215,0.00008114012,0.00002948759,0.0001123792,0.000134304,0.00237566,0.9602806,0.00145184,0.00007644109,0.01593504],"study_design_scores_gemma":[0.0001156231,0.0003816599,0.3618573,0.00005019698,0.0002855304,0.001174284,0.0005017326,0.05497007,0.5701223,0.007671196,0.002693139,0.0001769465],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951103,0.0009116838,0.003067494,0.00008450457,0.00001384562,0.000004194643,0.0000400791,0.00003284105,0.0007350428],"genre_scores_gemma":[0.9985265,0.000287745,0.0007979473,0.00003479432,0.00001713328,0.000003656116,0.00005404459,0.00002652235,0.0002516107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00118135,"threshold_uncertainty_score":0.00429523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004521885783165893,"score_gpt":0.2341524329552977,"score_spread":0.2296305471721318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}