{"id":"W328270376","doi":"10.1023/a:1019814713428","title":"Characterization of Asparagine Deamidation and Aspartate Isomerization in Recombinant Human Interleukin-11","year":2002,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Deamidation; Recombinant DNA; Asparagine; Chemistry; Biochemistry; Isomerization; Aspartic acid; Stereochemistry; Amino acid; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008792499,0.00006638074,0.00009223632,0.0001108287,0.00006279873,0.00001811944,0.0000996174,0.00006764803,0.0001414604],"category_scores_gemma":[0.0002620042,0.00006617919,0.00001683676,0.0002190127,0.0001488681,0.0000107969,0.00007359139,0.0001351642,0.000006508194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002031514,"about_ca_system_score_gemma":0.00001439695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001159688,"about_ca_topic_score_gemma":0.00001885854,"domain_scores_codex":[0.998834,0.0002736042,0.0002387163,0.0002493304,0.0001891968,0.0002151593],"domain_scores_gemma":[0.9995423,0.00002244501,0.00003897279,0.0001685194,0.0001442497,0.00008351564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004513831,0.0001734211,0.008610844,0.00004031695,0.00000435295,6.048676e-7,0.00008529793,0.000001255872,0.981638,0.0009579882,0.00002389805,0.008418843],"study_design_scores_gemma":[0.0007374519,0.0001625513,0.05354298,0.00001993903,0.000002885656,0.000002155983,0.00002069421,0.005081535,0.9243287,0.0003417589,0.01566027,0.00009908483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971966,0.0001869697,0.0007174676,0.001021577,0.00003033214,0.0003157077,0.000004996565,0.000005470125,0.0005209353],"genre_scores_gemma":[0.9988499,0.0004277499,0.00004391539,0.00004311399,0.00002508393,0.00004735526,0.00009663736,0.000008387686,0.0004578778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05730934,"threshold_uncertainty_score":0.2698709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1556430596101426,"score_gpt":0.4314008689855651,"score_spread":0.2757578093754225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}