{"id":"W328671606","doi":"10.1016/j.mce.2015.05.016","title":"Activin A, B and AB decrease progesterone production by down-regulating StAR in human granulosa cells","year":2015,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Gene knockdown; Endocrinology; Biology; Internal medicine; Activin receptor; Gene isoform; Granulosa cell; Receptor; Progesterone receptor; Small interfering RNA; Aromatase; Cell culture; Cell biology; Transforming growth factor; Ovary; Gene; Transfection; Estrogen receptor; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001386883,0.0002456508,0.0002255741,0.00008967306,0.00008293283,0.00003237621,0.0001194493,0.0001369396,0.000006193127],"category_scores_gemma":[0.00007665854,0.0002624026,0.00004045333,0.00007531087,0.0002029967,0.00001026761,0.0001729442,0.0001378294,0.000002423535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001977098,"about_ca_system_score_gemma":0.00006092999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001151138,"about_ca_topic_score_gemma":0.00004798564,"domain_scores_codex":[0.9983422,0.0001918271,0.0002561387,0.0006443191,0.0001367703,0.0004287299],"domain_scores_gemma":[0.9992653,0.000006998146,0.0000863234,0.0003419601,0.00005278987,0.000246675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008839125,0.000152008,0.003116594,0.00004052931,0.00003661314,0.00006999965,0.00009087445,0.00004784832,0.9947646,0.00004873032,0.0003801346,0.001163643],"study_design_scores_gemma":[0.001140407,0.0002748817,0.0003429353,0.00001752209,0.00003327146,0.00006433492,0.0001366002,0.00003030971,0.9935044,0.0001435583,0.004030888,0.0002808884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916669,0.007160684,0.0005296352,0.0001301577,0.00007587983,0.0003249872,0.000009591754,0.00002719035,0.00007496892],"genre_scores_gemma":[0.9988796,0.00005504064,0.0004677417,0.0000891376,0.00006468329,0.00005370913,0.0001951528,0.00003642088,0.0001585342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007212675,"threshold_uncertainty_score":0.9999828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009736649315238634,"score_gpt":0.2347771321451168,"score_spread":0.2250404828298782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}