{"id":"W33238524","doi":"","title":"Finger loop inhibitors of the HCV NS5B polymerase: discovery and prospects for new HCV therapy.","year":2006,"lang":"en","type":"article","venue":"PubMed","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS5B; Hepatitis C virus; NS5A; Allosteric regulation; Replicon; Benzimidazole; Polymerase; RNA polymerase; Virology; Enzyme; Drug discovery; Chemistry; Computational biology; Biology; Hepacivirus; RNA; Biochemistry; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001964522,0.0002883589,0.0002353022,0.0003070951,0.000104864,0.0002469196,0.0002400432,0.0002609889,0.001875196],"category_scores_gemma":[0.00009481647,0.0001060014,0.0001939337,0.0001403893,0.0001474485,0.0002299075,0.0001438651,0.0003423767,0.0005095942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003614357,"about_ca_system_score_gemma":0.0002114212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004803682,"about_ca_topic_score_gemma":0.002288351,"domain_scores_codex":[0.999954,0.000006421061,0.000002770881,0.000006177288,0.00001799811,0.00001265947],"domain_scores_gemma":[0.9999685,0.0000055228,0.000008444336,0.00000139719,0.000005294031,0.00001083198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001069031,0.0003700581,0.00122537,0.001271343,0.0000655488,0.0007532187,0.00008245343,0.0009867824,0.5103185,0.004223482,0.007117549,0.4725167],"study_design_scores_gemma":[0.0009628512,0.00600491,0.009312337,0.0002741123,0.0002474274,0.005767537,0.0001227408,0.004833901,0.5708752,0.002761543,0.3987636,0.0000737821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2144024,0.7493695,0.01582223,0.002646891,0.0006567441,0.0002096688,0.0005313954,0.0003504306,0.01601071],"genre_scores_gemma":[0.5484623,0.4079862,0.01563653,0.001246702,0.000330312,0.00009177683,0.0009012218,0.00003447328,0.02531052],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001875196,"threshold_uncertainty_score":0.00627315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0232215841081377,"score_gpt":0.2543560087015829,"score_spread":0.2311344245934452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}