{"id":"W347111618","doi":"10.1023/a:1009206926548","title":"Generation of Transgenic Mice and Germline Transmission of a Mammalian Artificial Chromosome Introduced into Embryos by Pronuclear Microinjection","year":2000,"lang":"en","type":"article","venue":"Chromosome Research","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biology; Microinjection; Germline; Transgene; Chromosome; Genetics; Embryo; Pronucleus; Genetically modified mouse; Cell biology; Molecular biology; Gene; Zygote; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001107733,0.0009125154,0.0006963023,0.001655417,0.0007400206,0.0005819299,0.001486263,0.001112968,0.005353908],"category_scores_gemma":[0.0005582301,0.001048619,0.0007218523,0.0008396419,0.0007590117,0.0005290514,0.0006965502,0.002142879,0.002927953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005522631,"about_ca_system_score_gemma":0.0006082417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001150307,"about_ca_topic_score_gemma":0.001753273,"domain_scores_codex":[0.9994209,0.00007115011,0.00009709562,0.0001353197,0.0001711067,0.0001044653],"domain_scores_gemma":[0.9991645,0.0002010412,0.0001966663,0.0001468472,0.00009077042,0.0002002929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002048515,0.00009601249,0.0001935991,0.00006082663,0.00001589,0.0001330077,0.00008522069,0.0001029229,0.9945766,0.002087272,0.0002251493,0.002218569],"study_design_scores_gemma":[0.000256832,0.0003205319,0.002802425,0.00003404544,0.00009767434,0.0007038299,0.00005097984,0.001588434,0.9729235,0.0005047486,0.02068745,0.00002950774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7369896,0.003402574,0.220015,0.001337015,0.0008647911,0.004306029,0.01363036,0.00324347,0.01621128],"genre_scores_gemma":[0.727739,0.005722126,0.1976507,0.0004822169,0.0001740505,0.004237106,0.01287489,0.001115157,0.05000485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005353908,"threshold_uncertainty_score":0.0179106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03885484407253388,"score_gpt":0.3179295510679669,"score_spread":0.2790747069954331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}