{"id":"W347111618","doi":"10.1023/a:1009206926548","title":"Generation of Transgenic Mice and Germline Transmission of a Mammalian Artificial Chromosome Introduced into Embryos by Pronuclear Microinjection","year":2000,"lang":"en","type":"article","venue":"Chromosome Research","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biology; Microinjection; Germline; Transgene; Chromosome; Genetics; Embryo; Pronucleus; Genetically modified mouse; Cell biology; Molecular biology; Gene; Zygote; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005879767,0.00014268,0.0002029638,0.0001069288,0.0001487318,0.00001887712,0.0001386382,0.0002103274,0.0001640373],"category_scores_gemma":[0.0000269967,0.0001346259,0.00007659227,0.0002735348,0.0003033313,0.000009722688,0.00003204847,0.0001748739,0.000007252789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002239057,"about_ca_system_score_gemma":0.00009858832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001107546,"about_ca_topic_score_gemma":0.00002437601,"domain_scores_codex":[0.998299,0.0001833223,0.0003866864,0.0005538845,0.0003069127,0.0002702121],"domain_scores_gemma":[0.9992959,0.00000709438,0.00005749188,0.0003007574,0.0002407465,0.00009803131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003064261,0.0002011014,0.00002220441,0.0001672936,0.00003122904,4.222422e-7,0.0002723997,0.00005805734,0.9537436,0.00001163198,0.0006376305,0.04454795],"study_design_scores_gemma":[0.0003973375,0.001211972,0.0002898678,0.00002515697,0.00001564422,0.00001674162,0.00005949313,0.0004674105,0.9866605,0.000042191,0.01067979,0.0001339171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963675,0.002458517,0.0002018876,0.0003727076,0.0000583649,0.0004172178,0.00002032155,0.000006883516,0.00009660403],"genre_scores_gemma":[0.9954153,0.002124886,0.00043178,0.000007231124,0.0006621276,0.00001835152,0.0001610005,0.00003188585,0.001147495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04441404,"threshold_uncertainty_score":0.5489886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03885484407253388,"score_gpt":0.3179295510679669,"score_spread":0.2790747069954331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}