{"id":"W347824162","doi":"10.3233/jnd-140000","title":"Human Growth Hormone Increases SMN Expression and Survival in Severe Spinal Muscular Atrophy Mouse Model","year":2014,"lang":"en","type":"article","venue":"Journal of Neuromuscular Diseases","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario","funders":"Institute of Genetics; FightSMA; Canadian Institutes of Health Research; University of Ottawa; Spinal Muscular Atrophy Foundation","keywords":"SMN1; SMA*; Spinal muscular atrophy; STAT5; Motor neuron; Endocrinology; Medicine; Internal medicine; Biology; Cancer research; Disease; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002467395,0.0006670426,0.0003930606,0.0006674537,0.0002131748,0.0002388408,0.0002623511,0.0005678837,0.002825551],"category_scores_gemma":[0.00009971605,0.0001743333,0.0005600813,0.0002858723,0.0003037752,0.0002259661,0.0001921591,0.001239772,0.0007362924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004075273,"about_ca_system_score_gemma":0.0003146653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007031568,"about_ca_topic_score_gemma":0.001361167,"domain_scores_codex":[0.9997621,0.00002996172,0.00002675403,0.0000490664,0.00007496223,0.00005717289],"domain_scores_gemma":[0.9998212,0.00001324078,0.0000585435,0.00001511728,0.00001869237,0.00007322511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009019783,0.0003466367,0.000720432,0.0001103395,0.00002006166,0.0001515354,0.00002765609,0.0001285444,0.994742,0.00007157597,0.0003620428,0.002417136],"study_design_scores_gemma":[0.0002537818,0.008656439,0.01623033,0.0000510047,0.0001323137,0.0008131793,0.000126849,0.002183364,0.963284,0.0001362389,0.00810819,0.00002431566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876764,0.004145914,0.002360192,0.0004921952,0.0002003508,0.0001026952,0.002259008,0.0003669322,0.002396349],"genre_scores_gemma":[0.9788095,0.003266827,0.003800303,0.0002432155,0.00005183783,0.0003542413,0.003525063,0.00005558407,0.009893475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002825551,"threshold_uncertainty_score":0.009452462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01664793869367159,"score_gpt":0.2800217511607604,"score_spread":0.2633738124670888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}