{"id":"W36061473","doi":"10.1089/jir.2014.0002","title":"Extracellular dsRNA: Its Function and Mechanism of Cellular Uptake","year":2014,"lang":"en","type":"review","venue":"Journal of Interferon & Cytokine Research","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"RNA silencing; Biology; Innate immune system; Pattern recognition receptor; Nucleic acid; Autoimmunity; Immune system; Interferon; Extracellular; RNA; Signal transduction; Receptor; Pathogen; Cell biology; Immunology; RNA interference; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002657208,0.0006630787,0.0009427102,0.00125828,0.0002367826,0.0009075211,0.0005824707,0.0009515456,0.001458163],"category_scores_gemma":[0.0002237978,0.0002571532,0.0002859712,0.001028044,0.0005258727,0.0009512745,0.000436727,0.001074554,0.001750394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000581574,"about_ca_system_score_gemma":0.0005724892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004835796,"about_ca_topic_score_gemma":0.0004436166,"domain_scores_codex":[0.9998842,0.0000152903,0.00001514739,0.00002851491,0.00004075101,0.00001597751],"domain_scores_gemma":[0.9999233,0.00002587534,0.00001348555,0.000003677107,0.00002389493,0.000009836526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001103691,0.00006427465,0.0002600645,0.01285308,0.00004352816,0.0003971417,0.0001061735,0.0004496214,0.03208969,0.009968044,0.009517136,0.9341408],"study_design_scores_gemma":[0.00001289254,0.0001360652,0.001194366,0.001576961,0.00005930269,0.002805886,0.00007941649,0.0001672576,0.01099262,0.003336141,0.9796123,0.0000267892],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003998286,0.9972417,0.0003600213,0.0001527625,0.0001282109,0.000004742606,0.00001876297,0.000006836109,0.001687045],"genre_scores_gemma":[0.002422595,0.9958854,0.0003558476,0.00009927256,0.0001231554,0.00001038424,0.00003200802,0.000001640352,0.001069718],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001458163,"threshold_uncertainty_score":0.004878044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07268114931503972,"score_gpt":0.3701672486135766,"score_spread":0.2974860992985369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}