{"id":"W374314792","doi":"10.1007/s10544-015-9967-4","title":"A microneedle-based method for the characterization of diffusion in skin tissue using doxorubicin as a model drug","year":2015,"lang":"en","type":"article","venue":"Biomedical Microdevices","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Canada Research Chairs","keywords":"Transdermal; Stratum corneum; Biomedical engineering; Materials science; Diffusion; Dermis; Pig skin; Drug delivery; Thermal diffusivity; Nanotechnology; Pathology; Pharmacology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002378892,0.0003978001,0.0002340755,0.000375924,0.000272937,0.0002636038,0.0002795457,0.0006229203,0.0007691497],"category_scores_gemma":[0.0003013645,0.0002006159,0.0001898352,0.0001706512,0.0002382953,0.0004324736,0.0002753006,0.00052066,0.0004017196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004706075,"about_ca_system_score_gemma":0.0003345713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008334606,"about_ca_topic_score_gemma":0.001908694,"domain_scores_codex":[0.9997914,0.00002289489,0.00001548072,0.00007618933,0.00007392972,0.00002013863],"domain_scores_gemma":[0.9997668,0.00008276657,0.00004898092,0.00002981951,0.00004892495,0.00002274065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007766731,0.000004116313,0.00002373028,0.00002270387,0.000001193755,0.000009422998,0.0000078847,0.00002278193,0.9980356,0.00005754232,0.00002320766,0.001784032],"study_design_scores_gemma":[0.00000209622,0.00003726182,0.000440221,0.000002781029,0.000003814511,0.0001005371,0.000005662915,0.001090262,0.9970251,0.00001874648,0.001267112,0.000006370363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.4575886,0.007732356,0.526889,0.0005576938,0.0002764146,0.0004033447,0.0008395682,0.001242799,0.004470279],"genre_scores_gemma":[0.732226,0.002879918,0.2562964,0.0002466814,0.00003535127,0.0002445277,0.0003452,0.00008491919,0.007640989],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.0008334606,"threshold_uncertainty_score":0.003414512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1286557505090863,"score_gpt":0.4701659054967738,"score_spread":0.3415101549876876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}