{"id":"W377179001","doi":"10.1096/fasebj.27.1_supplement.370.2","title":"Effects of folylpolyglutamate synthase modulation on CpG promoter DNA methylation and gene expression in human colon cancer cells","year":2013,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Biology; CpG site; Methylation; Regulation of gene expression; Gene expression; Cell cycle; Molecular biology; Cancer research; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001157465,0.0001643208,0.0002339511,0.0001592534,0.00009193514,0.0001626399,0.00006184834,0.0001492789,0.0008515591],"category_scores_gemma":[0.0001054363,0.0000979179,0.0001485852,0.0001891636,0.000115484,0.00006940301,0.00009757611,0.0002288287,0.0001420361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002306386,"about_ca_system_score_gemma":0.0001898953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002427288,"about_ca_topic_score_gemma":0.003484198,"domain_scores_codex":[0.999898,0.00002029022,0.000008210354,0.00002578241,0.00002067574,0.00002708227],"domain_scores_gemma":[0.9999425,0.00001739616,0.00001067301,0.000008745068,0.000008337793,0.00001227496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002841767,0.00001433453,0.0002965305,0.00002058068,0.000004907296,0.00001875074,0.00001522182,0.00004894137,0.9983365,0.00001461156,0.00001711174,0.0009283614],"study_design_scores_gemma":[0.00002495952,0.0005443816,0.01147445,0.000003242175,0.00001935363,0.00006906559,0.00003161046,0.0006409307,0.9862885,0.00001323941,0.0008866793,0.000003539243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975322,0.001250722,0.0003613478,0.00003708641,0.00001188088,0.00001225856,0.0002874511,0.00002049638,0.0004864263],"genre_scores_gemma":[0.9970437,0.0006482829,0.0007143392,0.00003031106,0.000003735547,0.00002443859,0.0003971569,0.000004715873,0.001133337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002427288,"threshold_uncertainty_score":0.004826307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008747943226672682,"score_gpt":0.2554663649889496,"score_spread":0.246718421762277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}