{"id":"W383619729","doi":"10.1016/j.ejmech.2015.05.034","title":"Styryl-N-phenyl-N′-(2-chloroethyl)ureas and styrylphenylimidazolidin-2-ones as new potent microtubule-disrupting agents using combretastatin A-4 as model","year":2015,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"Canadian Institutes of Health Research","keywords":"Moiety; Chemistry; Combretastatin; Stereochemistry; Tubulin; Ring (chemistry); Microtubule; Biological activity; In vitro; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001690422,0.0004523062,0.0006800164,0.00004523921,0.0001470544,0.0000980053,0.0005567817,0.0001239411,0.0005154958],"category_scores_gemma":[0.001959492,0.0003404892,0.0002088576,0.0001060544,0.0002398605,0.00018058,0.0002718095,0.0008556295,0.00002300363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001667641,"about_ca_system_score_gemma":0.0004574702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005328246,"about_ca_topic_score_gemma":4.394077e-7,"domain_scores_codex":[0.9970831,0.0001575185,0.0009536094,0.0004291151,0.0008681985,0.0005084061],"domain_scores_gemma":[0.9967694,0.000186564,0.0009762635,0.0003081062,0.0002930029,0.001466687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008273952,0.0002685884,0.001464302,0.0002295807,0.0002039629,0.001628138,0.0008364632,0.0005536526,0.9664303,0.000009206656,0.001641246,0.02590717],"study_design_scores_gemma":[0.007342079,0.0005425895,0.0006018447,0.002186691,0.0006727343,0.01269019,0.007250392,0.008610498,0.9505085,0.001375491,0.00694678,0.001272233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756916,0.001853609,0.0007566572,0.0007602345,0.0001086417,0.00004831307,0.00001343213,0.00003883973,0.02072872],"genre_scores_gemma":[0.9938464,0.0001632481,0.003452406,0.0003921226,0.001244155,4.708276e-7,0.000008126302,0.00006178734,0.0008312833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02463494,"threshold_uncertainty_score":0.9999047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09922953528473295,"score_gpt":0.301711088999526,"score_spread":0.2024815537147931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}