{"id":"W391137112","doi":"10.1371/journal.pone.0123691","title":"Do Housekeeping Genes Exist?","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"China Scholarship Council; Mitacs; Simon Fraser University; Compute Canada","keywords":"Housekeeping gene; Gene; Biology; Genome; Human genome; Computational biology; Genetics; Housekeeping; Transcriptome; Gene expression profiling; Gene nomenclature; Normalization (sociology); Gene expression; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001453261,0.0004560055,0.0009811607,0.00105826,0.0006862381,0.002419224,0.0008543867,0.001106014,0.003322932],"category_scores_gemma":[0.003023935,0.0002405481,0.0003763174,0.002075613,0.00264498,0.00317066,0.0009012346,0.0009753624,0.001251412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006932641,"about_ca_system_score_gemma":0.0004517213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007152263,"about_ca_topic_score_gemma":0.0006449638,"domain_scores_codex":[0.9989096,0.0001602667,0.00006049806,0.0004670821,0.0002049961,0.0001975605],"domain_scores_gemma":[0.9980743,0.0007832121,0.0003750479,0.0002702939,0.0003169209,0.0001801442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001698582,0.0001850173,0.1573594,0.0041619,0.0006406602,0.002306941,0.004064187,0.0004692748,0.1913409,0.1535251,0.01912151,0.4651266],"study_design_scores_gemma":[0.00008674904,0.0007146358,0.3283741,0.00117589,0.0006093429,0.007163136,0.006608412,0.001443293,0.06126326,0.1926165,0.3997547,0.0001899968],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6045494,0.2900022,0.03396932,0.02542962,0.002460488,0.00006268454,0.003769261,0.0004933926,0.03926369],"genre_scores_gemma":[0.9358317,0.04045375,0.007242219,0.006527608,0.0009320892,0.00007629377,0.002886884,0.0001124232,0.005937099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003322932,"threshold_uncertainty_score":0.01111633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07863987253676363,"score_gpt":0.2779822484999431,"score_spread":0.1993423759631794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}