{"id":"W394507619","doi":"10.1371/journal.pbio.1002155","title":"The Fitness Consequences of Aneuploidy Are Driven by Condition-Dependent Gene Effects","year":2015,"lang":"en","type":"article","venue":"PLoS Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institute for Advanced Research; National Cancer Institute; National Science Foundation; National Institutes of Health; March of Dimes Foundation; National Institute on Aging","keywords":"Biology; Aneuploidy; Genetics; Ploidy; Genetic Fitness; Genome; Amplicon; Gene; Saccharomyces cerevisiae; Experimental evolution; Population; Evolutionary biology; Chromosome; Polymerase chain reaction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004235,0.0001030484,0.0001374269,0.00001504671,0.00004597531,0.00000633636,0.0001896966,0.000119769,0.000003932963],"category_scores_gemma":[0.0001592826,0.00007424805,0.00003751088,0.00003426916,0.0002242634,0.000001155685,0.00006803175,0.00005438725,0.00000622164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007046118,"about_ca_system_score_gemma":0.0000408763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001502217,"about_ca_topic_score_gemma":0.00001612474,"domain_scores_codex":[0.9993457,0.00007068201,0.0001510256,0.0001934279,0.00006252124,0.0001766126],"domain_scores_gemma":[0.9994974,0.00005210171,0.00007646094,0.0002209422,0.00008624366,0.00006691948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002106252,0.00002833489,0.008332643,0.00001591898,0.00006186498,0.000001890247,0.00002164173,0.00008314282,0.9896799,0.00006211784,0.001524433,0.0001669936],"study_design_scores_gemma":[0.000362164,0.0002964282,0.001087993,0.000007350712,0.00001746775,0.00001433515,0.00007258246,0.00003707929,0.9946216,0.000207318,0.003173779,0.0001018508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936883,0.004081388,0.001397217,0.0002117557,0.00023131,0.000153305,0.00007185905,0.00001096408,0.0001538987],"genre_scores_gemma":[0.9991181,0.0002686467,0.0001180552,0.00008646465,0.00009183306,0.00003517009,0.0001408943,0.000009810033,0.0001310376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00724465,"threshold_uncertainty_score":0.3027748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111125215337335,"score_gpt":0.2970179517083653,"score_spread":0.2859066995549919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}