{"id":"W4200001072","doi":"10.3390/bioengineering8120209","title":"Guided Self-Assembly of ES-Derived Lung Progenitors into Biomimetic Tube Structures That Impact Cell Differentiation","year":2021,"lang":"en","type":"article","venue":"Bioengineering","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University Health Network; University of New Brunswick; Toronto General Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund; University Health Network","keywords":"Progenitor cell; Cell biology; Cellular differentiation; Extracellular matrix; SOX2; Decellularization; Induced pluripotent stem cell; Cell culture; Cell; Stem cell; Biology; Tissue engineering; Directed differentiation; Transcription factor; Embryonic stem cell; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113539,0.0002901741,0.0001173585,0.0001948787,0.0001134887,0.000265315,0.0001265625,0.0001920408,0.0004270001],"category_scores_gemma":[0.0001702134,0.0001951978,0.000154779,0.0001464841,0.0001905741,0.0001294837,0.0002150755,0.0002096607,0.0002032044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001532193,"about_ca_system_score_gemma":0.0001479537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002285675,"about_ca_topic_score_gemma":0.0006881938,"domain_scores_codex":[0.9999037,0.0000134346,0.00001018592,0.0000171523,0.00003947903,0.0000160937],"domain_scores_gemma":[0.9998665,0.00002995834,0.00004413462,0.00001673177,0.00001735156,0.00002532851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009932125,0.000006648169,0.0001346366,0.00001166318,0.000001884988,0.00002192186,0.00001375544,0.0003780961,0.9985499,0.00007372919,0.0000161519,0.0007817759],"study_design_scores_gemma":[0.000003677527,0.00008034408,0.001613482,0.000002957508,0.000004661852,0.00004600819,0.00001340752,0.003083961,0.993907,0.00002634993,0.001215218,0.000002972299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870958,0.0003758167,0.01026329,0.00004030508,0.0000258494,0.00004877747,0.0001228854,0.0001106805,0.001916574],"genre_scores_gemma":[0.982808,0.000387392,0.0145495,0.00003268104,0.00001014919,0.00005212858,0.000210522,0.00003252778,0.001917031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004270001,"threshold_uncertainty_score":0.001428485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286567053188852,"score_gpt":0.2700067797349688,"score_spread":0.2571411092030803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}