{"id":"W4200001628","doi":"10.1016/s2213-2600(21)00454-9","title":"Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":141,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Vertex Pharmaceuticals","keywords":"Ivacaftor; Cystic fibrosis; Clinical trial; Phases of clinical research; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002992347,0.001169829,0.005374108,0.0006586923,0.0004327374,0.00008730084,0.0008665444,0.0004640449,0.0003691359],"category_scores_gemma":[0.009404946,0.0007537,0.0004801232,0.001543798,0.001294252,0.0003985518,0.0003397053,0.00142219,0.0000191747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001425696,"about_ca_system_score_gemma":0.003007627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002522096,"about_ca_topic_score_gemma":0.0001225543,"domain_scores_codex":[0.9909455,0.0009507999,0.002415438,0.001639388,0.002147656,0.001901286],"domain_scores_gemma":[0.9849495,0.009953433,0.001103624,0.001976823,0.001018727,0.0009979164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.965737,0.001173302,0.0001172953,0.001324039,0.001174255,0.0003833982,0.0003774787,0.0002882145,0.02230138,0.0001116688,0.003760511,0.003251435],"study_design_scores_gemma":[0.9480411,0.01432608,0.001234485,0.001850658,0.001901449,0.0001248299,0.001436791,0.002072318,0.003042049,0.00002451548,0.02520169,0.000743972],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9639039,0.01445177,0.001023573,0.001180764,0.0003065569,0.01777628,0.0004040428,0.0001776817,0.0007754091],"genre_scores_gemma":[0.9824469,0.001356206,0.003308384,0.0008044282,0.005969984,0.00425199,0.00033944,0.0002919255,0.001230738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02144118,"threshold_uncertainty_score":0.9994914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07734527923377141,"score_gpt":0.373393846325249,"score_spread":0.2960485670914775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}