{"id":"W4200001628","doi":"10.1016/s2213-2600(21)00454-9","title":"Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":141,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Vertex Pharmaceuticals","keywords":"Ivacaftor; Cystic fibrosis; Clinical trial; Phases of clinical research; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00178422,0.002016451,0.004804438,0.0005032751,0.0005359047,0.001509488,0.001180002,0.003627782,0.007402594],"category_scores_gemma":[0.002986568,0.000867268,0.003422771,0.0003974375,0.00153975,0.00170598,0.0005661171,0.004309154,0.001320267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008440474,"about_ca_system_score_gemma":0.0009435613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001114848,"about_ca_topic_score_gemma":0.001764755,"domain_scores_codex":[0.9990408,0.0004273915,0.00006246854,0.0002127505,0.000070749,0.0001858004],"domain_scores_gemma":[0.9987152,0.0003950829,0.0003214436,0.00009702058,0.00007762424,0.0003936182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9896287,0.001861768,0.0002288693,0.0003510094,0.0006987249,0.00002020883,0.00003174448,0.000104515,0.001384886,0.00003863485,0.0002713816,0.005379695],"study_design_scores_gemma":[0.9638221,0.03398121,0.001048311,0.00003156565,0.0004712506,0.00001988794,0.00001913319,0.0001397252,0.0001881989,0.00008307444,0.0001814808,0.00001403385],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862579,0.008259068,0.00052736,0.0009177507,0.0006330496,0.001295887,0.0007652369,0.0001201537,0.001223691],"genre_scores_gemma":[0.9898913,0.002727473,0.0009787338,0.0009664122,0.0005004232,0.001750454,0.0006423668,0.00003431905,0.002508387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007402594,"threshold_uncertainty_score":0.02476418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07734527923377141,"score_gpt":0.373393846325249,"score_spread":0.2960485670914775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}