{"id":"W4200002977","doi":"10.3390/cancers13236124","title":"Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministerio de Ciencia e Innovación; China Scholarship Council; CNIB","keywords":"Pancreatic cancer; Endoplasmic reticulum; Autophagy; Cancer research; Apoptosis; Cancer cell; Cancer stem cell; Biology; Cancer; Cell biology; Chemistry; Internal medicine; Stem cell; Medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001051412,0.0002538646,0.0002588649,0.0001540975,0.00009643997,0.0001428305,0.0001160006,0.0001657833,0.0005454035],"category_scores_gemma":[0.00007406811,0.0001034705,0.0001905697,0.000147339,0.0001195965,0.0001265532,0.0001506273,0.0003723181,0.0001503579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001707479,"about_ca_system_score_gemma":0.0001724977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004497187,"about_ca_topic_score_gemma":0.0007390914,"domain_scores_codex":[0.9999298,0.0000129556,0.0000120482,0.00001441131,0.0000154651,0.00001527067],"domain_scores_gemma":[0.9999521,0.00001100301,0.00001231577,0.000006657251,0.000008497636,0.000009565792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002984707,0.00006405852,0.0001853651,0.00006625654,0.000009248601,0.0000704682,0.00003438069,0.0001235452,0.9971275,0.0000663693,0.00003651132,0.001917856],"study_design_scores_gemma":[0.00002401768,0.0006876321,0.00174019,0.000005783505,0.0000125736,0.0001344511,0.0000156526,0.0004851673,0.9960069,0.00001658163,0.0008691456,0.000002000679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972093,0.001021656,0.0006623212,0.00004262918,0.00001212683,0.00002178798,0.0001679179,0.00003100992,0.0008313012],"genre_scores_gemma":[0.9958953,0.001256755,0.00124469,0.00005643833,0.000007941773,0.00003884076,0.0005623935,0.000008464162,0.0009292253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005454035,"threshold_uncertainty_score":0.001824558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009405966664418643,"score_gpt":0.2478416554842032,"score_spread":0.2384356888197846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}