{"id":"W4200003507","doi":"10.1093/neuonc/noab196.283","title":"CTNI-58. EFFICACY AND SAFETY OF LAROTRECTINIB IN ADULT AND PEDIATRIC PATIENTS WITH TROPOMYOSIN RECEPTOR KINASE (TRK) FUSION-POSITIVE PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trk receptor; Medicine; Internal medicine; Oncology; Gastroenterology; Receptor; Neurotrophin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003540188,0.000281583,0.0006552637,0.0001773816,0.0001310914,0.0003389025,0.0002133983,0.0002453968,0.001511502],"category_scores_gemma":[0.0004804635,0.0001246759,0.0003931524,0.0002223661,0.0002265799,0.0003009034,0.0001324723,0.0008684914,0.0003636095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007649128,"about_ca_system_score_gemma":0.0007252424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001208225,"about_ca_topic_score_gemma":0.003621429,"domain_scores_codex":[0.9998544,0.00004135316,0.00001410341,0.00002984633,0.00002950658,0.00003076085],"domain_scores_gemma":[0.9996963,0.00004220592,0.00008749199,0.00001183577,0.00002932989,0.0001328977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1630807,0.008018801,0.1528619,0.002052887,0.001241721,0.002611245,0.0004427744,0.004855054,0.08959462,0.0006916324,0.02071708,0.5538316],"study_design_scores_gemma":[0.05891317,0.2599115,0.5743252,0.0005577832,0.002208352,0.01060212,0.0004161653,0.009113722,0.04126329,0.0004652874,0.04212571,0.00009774687],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844281,0.0101524,0.000263618,0.0002619744,0.00004232115,0.0001670106,0.001101552,0.0000721606,0.003510796],"genre_scores_gemma":[0.9932305,0.003419627,0.0004052524,0.0002530207,0.00004069396,0.0001418855,0.001679211,0.00001227111,0.0008175335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001511502,"threshold_uncertainty_score":0.005549788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005435077052758422,"score_gpt":0.2262355109578392,"score_spread":0.2208004339050808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}