{"id":"W4200005408","doi":"10.1093/neuonc/noab196.251","title":"CTNI-26. PHASE 2 STUDY OF DIANHYDROGALACTITOL (VAL-083) IN PATIENTS WITH MGMT-UNMETHYLATED, BEVACIZUMAB-NAÏVE GLIOBLASTOMA IN THE RECURRENT AND ADJUVANT SETTING","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Temozolomide; Medicine; Bevacizumab; Oncology; Internal medicine; Adjuvant; Radiation therapy; Methyltransferase; Chemoradiotherapy; O-6-methylguanine-DNA methyltransferase; Chemotherapy; DNA; Biology; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001010322,0.001660178,0.001563935,0.0004092831,0.0003368229,0.0008433278,0.0008044408,0.001015895,0.00227939],"category_scores_gemma":[0.0005229685,0.0005933707,0.0009980031,0.0003779478,0.0008839938,0.0005701467,0.0002740358,0.002728386,0.0007035194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001022033,"about_ca_system_score_gemma":0.001921167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00191935,"about_ca_topic_score_gemma":0.005950375,"domain_scores_codex":[0.9997286,0.0001157419,0.00001157802,0.00005102462,0.00002171866,0.00007133721],"domain_scores_gemma":[0.9995647,0.00003454761,0.00006459905,0.0000304822,0.00002597307,0.0002796667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7866386,0.08316664,0.005271587,0.0004619069,0.0008257453,0.0002812686,0.000229573,0.002108248,0.06368171,0.0002803408,0.00282279,0.05423158],"study_design_scores_gemma":[0.4257331,0.5576971,0.008189691,0.00002238723,0.0003449261,0.0002028157,0.00005129442,0.0009252462,0.004971165,0.0001275611,0.001702865,0.00003200495],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955406,0.0009244637,0.0002314603,0.0002240429,0.00009161985,0.001310283,0.0006027749,0.00007048567,0.001004319],"genre_scores_gemma":[0.9916878,0.001141972,0.0009565399,0.0004661815,0.0001081573,0.001500906,0.00175016,0.00002464192,0.002363506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00227939,"threshold_uncertainty_score":0.007625341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126455871435565,"score_gpt":0.3034678738446902,"score_spread":0.2908222867011336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}