{"id":"W4200012043","doi":"10.3390/antiox11010052","title":"Hydrogen Peroxide and Amyotrophic Lateral Sclerosis: From Biochemistry to Pathophysiology","year":2021,"lang":"en","type":"review","venue":"Antioxidants","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"SOD1; Amyotrophic lateral sclerosis; Pathogenesis; Superoxide dismutase; Reactive oxygen species; Chemistry; Protein aggregation; Biochemistry; Cell biology; Oxidative stress; Biology; Medicine; Pathology; Immunology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006731318,0.0006764495,0.0009224499,0.001761737,0.0003972565,0.001753202,0.0007753016,0.002090164,0.002010651],"category_scores_gemma":[0.0006368755,0.0002554522,0.0003424514,0.001279017,0.001944316,0.002193979,0.001307559,0.002251352,0.001205853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009914128,"about_ca_system_score_gemma":0.000936281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001157676,"about_ca_topic_score_gemma":0.0007910875,"domain_scores_codex":[0.9997181,0.00008012225,0.00003289026,0.00005858466,0.00007361131,0.00003654388],"domain_scores_gemma":[0.9996643,0.00009634803,0.00007139592,0.00001552575,0.0000860123,0.00006640908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001085435,0.0007367301,0.008838625,0.01341591,0.0003065796,0.00529176,0.001438388,0.0007844681,0.01660957,0.05242346,0.08585967,0.8132094],"study_design_scores_gemma":[0.00011464,0.001083534,0.02195045,0.006070661,0.0002688336,0.01650138,0.001391351,0.0005870129,0.003308178,0.08787901,0.8606955,0.0001493662],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009303209,0.9942872,0.0001280442,0.003402369,0.0005398228,0.000003253603,0.00001036722,0.000008191126,0.0006905255],"genre_scores_gemma":[0.01513462,0.9775447,0.0002622384,0.001890912,0.003551483,0.00001568862,0.00002749657,0.000004707165,0.001568163],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002090164,"threshold_uncertainty_score":0.007193267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06569897748681383,"score_gpt":0.3442582279333558,"score_spread":0.278559250446542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}