{"id":"W4200012043","doi":"10.3390/antiox11010052","title":"Hydrogen Peroxide and Amyotrophic Lateral Sclerosis: From Biochemistry to Pathophysiology","year":2021,"lang":"en","type":"review","venue":"Antioxidants","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"SOD1; Amyotrophic lateral sclerosis; Pathogenesis; Superoxide dismutase; Reactive oxygen species; Chemistry; Protein aggregation; Biochemistry; Cell biology; Oxidative stress; Biology; Medicine; Pathology; Immunology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001641565,0.0006961041,0.002869697,0.0002061746,0.0001261301,0.0000854697,0.0003480728,0.0007582983,0.0004475752],"category_scores_gemma":[0.0001918719,0.0005527519,0.0005669941,0.0005380561,0.0001762792,0.00007374035,0.000662161,0.0008286746,0.0005022594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002059502,"about_ca_system_score_gemma":0.0004490885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001980646,"about_ca_topic_score_gemma":0.00000362183,"domain_scores_codex":[0.9962863,0.0002588448,0.000788547,0.001353061,0.0005081145,0.0008051253],"domain_scores_gemma":[0.9978501,0.0001273464,0.0001961237,0.001013602,0.0001484303,0.0006643599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006339395,0.0002344568,0.0001902494,0.006950214,0.001022751,0.000915778,0.0000778646,2.243496e-7,0.1402385,0.000007915285,0.001642415,0.8486562],"study_design_scores_gemma":[0.003549424,0.001068976,0.02586554,0.1932579,0.004603435,0.0007481482,0.00005587121,0.00001713752,0.005849941,0.0002184785,0.7612497,0.003515405],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3000138,0.6987994,0.00000194121,0.0001750298,0.0001002174,0.0006028031,0.0001884698,0.00006326045,0.00005502355],"genre_scores_gemma":[0.009071974,0.9874262,0.0005182674,0.0005487928,0.0006619342,0.0001553856,0.000542048,0.0001450978,0.0009303237],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8451408,"threshold_uncertainty_score":0.9996924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06569897748681383,"score_gpt":0.3442582279333558,"score_spread":0.278559250446542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}