{"id":"W4200013870","doi":"10.1101/2021.11.02.466874","title":"Dysfunction of exocytosis causes catecholamine hypersecretion in patient with pheochromocytoma","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Adrenal and Paraganglionic Tumors","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Région Normandie; Ligue Contre le Cancer; Université de Strasbourg; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Alliance Nationale pour les Sciences de la Vie et de la Santé","keywords":"Exocytosis; Pheochromocytoma; Catecholamine; Secretion; Adrenal medulla; Endocrinology; Internal medicine; Calcium; Cancer research; Chemistry; Medicine; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005469,0.0003610935,0.0004480616,0.0005056729,0.0004158444,0.0003475323,0.0001567734,0.0007182491,0.001231665],"category_scores_gemma":[0.0005256811,0.0001341267,0.0002056306,0.0002551292,0.0003063511,0.0002821032,0.0002201556,0.000613348,0.000267054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001957917,"about_ca_system_score_gemma":0.0001039908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004478981,"about_ca_topic_score_gemma":0.0003378016,"domain_scores_codex":[0.9998719,0.00001237,0.00001160037,0.00004951504,0.00002330931,0.00003132022],"domain_scores_gemma":[0.9997981,0.00006927274,0.0000321037,0.00001636071,0.00001623348,0.00006801327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001961317,0.000215843,0.3742447,0.0001189705,0.00007511729,0.4919952,0.0008117671,0.0002949813,0.1179796,0.0002924527,0.0008923918,0.01111763],"study_design_scores_gemma":[0.00004745281,0.000880297,0.3792966,0.0000242197,0.00009559895,0.5748662,0.0004620631,0.002869732,0.03897136,0.0004139344,0.002038656,0.00003387673],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977891,0.000497974,0.0006361447,0.0002100878,0.00003355019,0.00001087431,0.0001049545,0.00003712027,0.0006800771],"genre_scores_gemma":[0.9995427,0.00007467361,0.00011499,0.00004175779,0.00002054802,0.000001507915,0.00003435809,0.000003972644,0.0001656485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001231665,"threshold_uncertainty_score":0.00412035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220281767109671,"score_gpt":0.21081583837432,"score_spread":0.1986130207032233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}