{"id":"W4200013870","doi":"10.1101/2021.11.02.466874","title":"Dysfunction of exocytosis causes catecholamine hypersecretion in patient with pheochromocytoma","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Adrenal and Paraganglionic Tumors","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Région Normandie; Ligue Contre le Cancer; Université de Strasbourg; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Alliance Nationale pour les Sciences de la Vie et de la Santé","keywords":"Exocytosis; Pheochromocytoma; Catecholamine; Secretion; Adrenal medulla; Endocrinology; Internal medicine; Calcium; Cancer research; Chemistry; Medicine; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002377305,0.0004505896,0.0008271265,0.0004156425,0.00005141902,0.00003952866,0.0001324557,0.0004056372,0.00009950346],"category_scores_gemma":[0.000148989,0.000403901,0.0001381768,0.0008041726,0.0001253039,0.0001170571,0.0001748557,0.0007442757,0.00001051968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003995085,"about_ca_system_score_gemma":0.0008632367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002938,"about_ca_topic_score_gemma":0.00003457957,"domain_scores_codex":[0.9976274,0.0001066177,0.0006119196,0.0007673948,0.0005195405,0.0003671388],"domain_scores_gemma":[0.9978315,0.00004206974,0.0004509522,0.0008658396,0.0006165837,0.0001930727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001319832,0.001377822,0.04333718,0.002832755,0.0005075833,0.0163238,0.0001718475,0.0004501589,0.9334764,0.0001206226,0.00006810323,0.00001391761],"study_design_scores_gemma":[0.001488627,0.0005049474,0.2820143,0.002630382,0.0002935695,0.000005050299,0.00004870038,0.0001530103,0.7123033,2.7183e-7,0.0000966954,0.0004611331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972224,0.001023988,0.0003717016,0.0001012361,0.0003580608,0.0007045693,0.00005897235,0.0001395742,0.00001944898],"genre_scores_gemma":[0.9978337,0.00009404101,0.001574289,0.0001013496,0.0001512565,0.0001496323,0.000003418631,0.00008760147,0.000004731836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2386771,"threshold_uncertainty_score":0.9998413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220281767109671,"score_gpt":0.21081583837432,"score_spread":0.1986130207032233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}