{"id":"W4200016728","doi":"10.3390/cancers14010014","title":"Tipping Growth Inhibition into Apoptosis by Combining Treatment with MDM2 and WIP1 Inhibitors in p53WT Uterine Leiomyosarcoma","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Sarcoma UK","keywords":"Apoptosis; Growth inhibition; Mdm2; Cancer research; Chemistry; Pharmacology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001789703,0.0002363739,0.000454671,0.0003005868,0.0001070509,0.0001997459,0.00019425,0.0001579254,0.0008650912],"category_scores_gemma":[0.0001057122,0.0001222189,0.0002349588,0.0001763701,0.0001970208,0.0001787027,0.0001940423,0.0003966329,0.0001863405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001776084,"about_ca_system_score_gemma":0.000237517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003214807,"about_ca_topic_score_gemma":0.001219292,"domain_scores_codex":[0.9999206,0.00002032826,0.000009729608,0.00001108947,0.00001397101,0.00002425514],"domain_scores_gemma":[0.9999623,0.00001014622,0.000007166359,0.000004804627,0.000002444065,0.0000130796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002733987,0.0006974122,0.001142788,0.0002958788,0.00004873937,0.0004714438,0.00006757028,0.0008416017,0.9559813,0.000208115,0.0004228428,0.03708829],"study_design_scores_gemma":[0.0002905307,0.01006775,0.01088954,0.00001945985,0.00008470477,0.0009289492,0.00008923514,0.002194569,0.9705933,0.0001314286,0.00469865,0.00001196118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943046,0.003161781,0.0008741225,0.0001057888,0.00003764169,0.0000558624,0.0001609005,0.0000747667,0.0012245],"genre_scores_gemma":[0.9957798,0.0017847,0.001260993,0.0000367668,0.0000171411,0.00005198238,0.0002148598,0.000008553165,0.0008452615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008650912,"threshold_uncertainty_score":0.002894044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009041873764053064,"score_gpt":0.2419360994041564,"score_spread":0.2328942256401033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}