{"id":"W4200016728","doi":"10.3390/cancers14010014","title":"Tipping Growth Inhibition into Apoptosis by Combining Treatment with MDM2 and WIP1 Inhibitors in p53WT Uterine Leiomyosarcoma","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Sarcoma UK","keywords":"Apoptosis; Growth inhibition; Mdm2; Cancer research; Chemistry; Pharmacology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006126188,0.0002219112,0.0003471875,0.0001367101,0.0000691993,0.00002841126,0.00002562757,0.00009981803,0.00003416165],"category_scores_gemma":[0.00002068021,0.0002087724,0.00004975354,0.0004707935,0.0001036211,0.0001022102,0.00003927969,0.0001825538,0.000003557733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002722493,"about_ca_system_score_gemma":0.0006541747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001849326,"about_ca_topic_score_gemma":0.000402696,"domain_scores_codex":[0.9988076,0.00003856497,0.0002429696,0.0004365005,0.0002011612,0.0002731754],"domain_scores_gemma":[0.9994462,0.00002339624,0.0000772126,0.0002075785,0.00007792109,0.0001677661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006955909,0.0001908457,0.01518042,0.0003907378,0.0003447053,0.0008482331,0.004081995,0.0001542863,0.947747,0.0002859373,0.002270361,0.02780992],"study_design_scores_gemma":[0.01090959,0.001849066,0.001092584,0.001748606,0.0001614419,0.0002551575,0.001589191,0.0005241688,0.9724315,0.00007973371,0.008910271,0.0004486251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944257,0.002505627,0.0003345556,0.000972315,0.0001660648,0.0003392857,0.00001402615,0.00006267702,0.001179816],"genre_scores_gemma":[0.9976041,0.0008365463,0.0006292818,0.0004277007,0.00007897031,0.0001071457,0.0001252507,0.00004501929,0.0001459666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0273613,"threshold_uncertainty_score":0.851349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009041873764053064,"score_gpt":0.2419360994041564,"score_spread":0.2328942256401033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}