{"id":"W4200017820","doi":"10.1371/journal.ppat.1010123","title":"RSK1 SUMOylation is required for KSHV lytic replication","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; School of Medicine, Shanghai Jiao Tong University; National Institutes of Health; Shanghai Jiao Tong University; Science and Technology Commission of Shanghai Municipality; National Institute of Dental and Craniofacial Research; National Natural Science Foundation of China; Shanghai Municipal Health Commission","keywords":"SUMO protein; Lytic cycle; Phosphorylation; Cell biology; Kaposi's sarcoma-associated herpesvirus; Kinase; Biology; Chemistry; Virology; Biochemistry; Ubiquitin; Virus; Herpesviridae; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001010479,0.0002613398,0.0002351502,0.0001561344,0.0002744746,0.0003773211,0.0001941437,0.0002155958,0.002209091],"category_scores_gemma":[0.0001566895,0.0001530791,0.0002825161,0.0001227693,0.0002014293,0.0002341872,0.0002685018,0.0003842146,0.001063939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000320664,"about_ca_system_score_gemma":0.00023513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005594792,"about_ca_topic_score_gemma":0.0005742307,"domain_scores_codex":[0.9998583,0.00001788813,0.00001895931,0.00003431039,0.00003559067,0.00003494792],"domain_scores_gemma":[0.9997796,0.00002184976,0.00007819068,0.0000292665,0.00002003602,0.0000709901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001084083,0.00001469376,0.0005069624,0.00002802027,0.000003225065,0.00006658264,0.00001329719,0.00004267141,0.9982456,0.00009983558,0.00004767568,0.0008229809],"study_design_scores_gemma":[0.00001023736,0.000106146,0.02782497,0.000007558624,0.00001065819,0.0005762907,0.00005464073,0.0009669045,0.9670697,0.00007975786,0.00328536,0.000007828547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963641,0.0008029253,0.001159131,0.00008027768,0.00002261798,0.000008672023,0.0005053435,0.0001037591,0.0009532637],"genre_scores_gemma":[0.9970713,0.0002096797,0.000478173,0.00001637726,0.000004151299,0.000006826225,0.0006955217,0.00002062773,0.001497261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002209091,"threshold_uncertainty_score":0.007390141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04372319558383413,"score_gpt":0.2992467134240376,"score_spread":0.2555235178402035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}