{"id":"W4200017820","doi":"10.1371/journal.ppat.1010123","title":"RSK1 SUMOylation is required for KSHV lytic replication","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; School of Medicine, Shanghai Jiao Tong University; National Institutes of Health; Shanghai Jiao Tong University; Science and Technology Commission of Shanghai Municipality; National Institute of Dental and Craniofacial Research; National Natural Science Foundation of China; Shanghai Municipal Health Commission","keywords":"SUMO protein; Lytic cycle; Phosphorylation; Cell biology; Kaposi's sarcoma-associated herpesvirus; Kinase; Biology; Chemistry; Virology; Biochemistry; Ubiquitin; Virus; Herpesviridae; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001098207,0.00009406507,0.0001907554,0.00004047863,0.0000868924,0.00001585832,0.00003548884,0.0001003653,0.0001573976],"category_scores_gemma":[0.0004815748,0.00009552662,0.0001241657,0.0002137306,0.00001617048,0.00005712286,0.00001381472,0.00006021681,0.00004908735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001413741,"about_ca_system_score_gemma":0.000174548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000653728,"about_ca_topic_score_gemma":0.00001049366,"domain_scores_codex":[0.9990461,0.00001941002,0.0002042804,0.0003464133,0.0001843444,0.0001994557],"domain_scores_gemma":[0.999077,0.00003840672,0.00009085677,0.0004520138,0.0002633229,0.00007836508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003115742,0.0005934623,0.03490167,0.0003532449,0.0003075096,0.00003624313,0.001613836,0.00001215108,0.9061195,0.001095852,0.03448354,0.02017146],"study_design_scores_gemma":[0.02374935,0.001971106,0.1230653,0.0008430464,0.003709866,0.00008035685,0.0040645,0.02975633,0.6801354,0.01726023,0.1136912,0.001673283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776725,0.001047297,0.001530292,0.01063034,0.0001649244,0.0008527477,0.0001847932,0.0001653619,0.007751738],"genre_scores_gemma":[0.9908512,0.0001918402,0.001329793,0.00267817,0.0001809198,0.0001273747,0.0004893469,0.00003439812,0.004116949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.225984,"threshold_uncertainty_score":0.3895462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04372319558383413,"score_gpt":0.2992467134240376,"score_spread":0.2555235178402035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}