{"id":"W4200020923","doi":"10.1002/pbc.29520","title":"A novel central nervous system embryonal tumor successfully treated with multi‐modal therapy highlights limitation of methylation‐based tumor classification","year":2021,"lang":"en","type":"letter","venue":"Pediatric Blood & Cancer","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Medicine; Central nervous system; Methylation; Modal; Bioinformatics; Computational biology; Internal medicine; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001935194,0.0004452823,0.0006543448,0.0005694258,0.001149918,0.0006609311,0.0005672116,0.002960896,0.001227485],"category_scores_gemma":[0.001008934,0.0002340004,0.000547232,0.0004754979,0.000539474,0.0008421663,0.0005044309,0.002467031,0.0004662083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001122217,"about_ca_system_score_gemma":0.0006102555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002402754,"about_ca_topic_score_gemma":0.006094629,"domain_scores_codex":[0.9998325,0.00001799857,0.00001856548,0.00004760987,0.00003471102,0.00004859558],"domain_scores_gemma":[0.9997053,0.0001021861,0.00003703346,0.00003729339,0.00002796032,0.0000901329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00007191924,0.00003405421,0.002419855,0.00004818594,0.00001123872,0.9819393,0.0001192983,0.0002827222,0.003119266,0.0008959465,0.002421387,0.008636907],"study_design_scores_gemma":[0.00003113227,0.0001371296,0.00675302,0.00002933864,0.00003123909,0.9783661,0.0001384077,0.002405074,0.003422868,0.001503655,0.007162713,0.00001932611],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8520262,0.009371743,0.02107289,0.07641402,0.004062307,0.0003337922,0.000997367,0.0007843534,0.03493733],"genre_scores_gemma":[0.9593495,0.003940007,0.01003614,0.009913611,0.002283477,0.00006787563,0.0003884416,0.0001092233,0.01391174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002960896,"threshold_uncertainty_score":0.008142352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03643900987823645,"score_gpt":0.2637673359769677,"score_spread":0.2273283260987312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}