{"id":"W4200020977","doi":"10.1093/biolre/ioab226","title":"<i>KIF3B</i> gene silent variant leading to sperm morphology and motility defects and male infertility","year":2021,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Royan Institute","keywords":"Intraflagellar transport; Biology; Axoneme; Sperm; Sperm motility; Exon; Male infertility; Genetics; Andrology; Cell biology; Gene; Infertility; Flagellum; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002304523,0.0001096934,0.0001820865,0.0000280556,0.00005328865,0.00000523378,0.00004599115,0.0001363836,0.00002737118],"category_scores_gemma":[0.000505863,0.0001102876,0.0000385321,0.00006380791,0.0001773735,0.000002635154,0.0001561199,0.00004482112,0.000002841019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007266803,"about_ca_system_score_gemma":0.00005590769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002368059,"about_ca_topic_score_gemma":0.00001027527,"domain_scores_codex":[0.9987886,0.0001213388,0.0001805171,0.0007107199,0.00003628704,0.0001625288],"domain_scores_gemma":[0.9992985,0.000009280223,0.00005591974,0.0004282716,0.00009946516,0.0001085639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006392794,0.00006024932,0.08668271,0.00003136744,0.00002296496,0.000004593744,0.00003225256,0.00000738215,0.9098322,0.00001744485,0.0002848365,0.00296012],"study_design_scores_gemma":[0.000227879,0.0002410505,0.1805143,0.00000484852,0.00002440335,0.000303148,0.00004143624,0.000002122089,0.8132795,0.0001689663,0.005103602,0.00008875281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887706,0.009341579,0.0009092625,0.0004034278,0.000234918,0.0001452704,0.00003167391,0.000007784526,0.0001554909],"genre_scores_gemma":[0.9968781,0.000635694,0.001795758,0.0001510619,0.0001513275,0.0000109851,0.000091031,0.000007149446,0.0002788929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09655264,"threshold_uncertainty_score":0.44974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158960251105076,"score_gpt":0.2501615635988538,"score_spread":0.238571961087803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}