{"id":"W4200020977","doi":"10.1093/biolre/ioab226","title":"<i>KIF3B</i> gene silent variant leading to sperm morphology and motility defects and male infertility","year":2021,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Royan Institute","keywords":"Intraflagellar transport; Biology; Axoneme; Sperm; Sperm motility; Exon; Male infertility; Genetics; Andrology; Cell biology; Gene; Infertility; Flagellum; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008508914,0.0004260111,0.0002177204,0.000545136,0.0003403368,0.0001684422,0.0001426168,0.0003326528,0.002904982],"category_scores_gemma":[0.0004067237,0.0001109566,0.000221761,0.000434078,0.0003700259,0.00008625023,0.000160381,0.0002196658,0.0003014242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001339946,"about_ca_system_score_gemma":0.0001227295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001421306,"about_ca_topic_score_gemma":0.00124243,"domain_scores_codex":[0.9998902,0.00001300836,0.00001148273,0.00003510352,0.00002477024,0.00002541496],"domain_scores_gemma":[0.9998568,0.00002372848,0.0000744875,0.000006226486,0.00001204976,0.00002661266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001597991,0.000149481,0.7514328,0.0002279554,0.0002841738,0.09684891,0.0005652584,0.0001965483,0.1248972,0.0006746117,0.001345817,0.02177928],"study_design_scores_gemma":[0.00004900979,0.0003576329,0.8337811,0.00004044849,0.0001485842,0.1544871,0.0002184915,0.0002808648,0.007194609,0.0002095545,0.003219539,0.00001316064],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978811,0.0006629628,0.0003105535,0.00006386687,0.00001359658,0.00001220433,0.0001746723,0.00001777096,0.0008632646],"genre_scores_gemma":[0.9988826,0.0002591269,0.0001122091,0.00004477216,0.00002346165,0.000004955923,0.0001596694,0.000005211481,0.0005079327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002904982,"threshold_uncertainty_score":0.00971812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158960251105076,"score_gpt":0.2501615635988538,"score_spread":0.238571961087803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}