{"id":"W4200028620","doi":"10.1016/s1470-2045(21)00589-1","title":"Residual cancer burden after neoadjuvant chemotherapy and long-term survival outcomes in breast cancer: a multicentre pooled analysis of 5161 patients","year":2021,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":437,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences; Cancer Prevention and Research Institute of Texas; Genentech; National Institutes of Health; Instituto de Investigación Sanitaria Gregorio Marañón; Bristol-Myers Squibb; Max-Planck-Gesellschaft; Eisai; National Institute for Health and Care Research; University of California, San Francisco; Cancer Research UK; Puma Biotechnology; Syndax Pharmaceuticals; Daiichi Sankyo Europe; National Cancer Institute; Gilead Sciences; PharmaMar; Celgene; Intas Pharmaceuticals; Eli Lilly and Company; AstraZeneca; European Regional Development Fund; Breast Cancer Research Foundation; Instituto de Salud Carlos III; Amgen; Pfizer","keywords":"Pooled analysis; Chemotherapy; Breast cancer; Cancer; Survival analysis; Meta-analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001182117,0.0001867296,0.0007267459,0.00005631631,0.00004049445,0.000008761603,0.0001499954,0.0001192333,0.0001162218],"category_scores_gemma":[0.00001956214,0.0001319851,0.00009977836,0.000227396,0.0001503787,0.000004097689,0.0001727889,0.00009282042,7.491733e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009848894,"about_ca_system_score_gemma":0.0001356038,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001443321,"about_ca_topic_score_gemma":0.02707655,"domain_scores_codex":[0.9987599,0.0001992415,0.000249736,0.0003581706,0.0001258603,0.0003071013],"domain_scores_gemma":[0.9992783,0.00006117127,0.0001414789,0.0003379654,0.0001394931,0.00004161141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001203836,0.0002112371,0.9797904,0.00002355119,0.002923978,0.00001835733,0.0007281998,0.00007722317,0.002185301,0.000003181,0.00008816181,0.01274659],"study_design_scores_gemma":[0.004509296,0.00005610217,0.992621,0.00002273349,0.0008954391,0.000003147839,0.0001435917,0.0000150715,0.001221509,0.000004433969,0.0003714911,0.0001362023],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860523,0.003401025,0.000003275675,0.00958838,0.0001634946,0.0001597053,0.0005674955,0.000005908491,0.00005845555],"genre_scores_gemma":[0.9930668,0.005387521,0.00004551693,0.0008941935,0.0002433033,0.000129279,0.0000990982,0.00001609683,0.0001181648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02563323,"threshold_uncertainty_score":0.9906768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01283719424098698,"score_gpt":0.3124301090058624,"score_spread":0.2995929147648754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}