{"id":"W4200030049","doi":"10.1101/2021.12.19.473380","title":"SARS-CoV-2 Omicron Variant: ACE2 Binding, Cryo-EM Structure of Spike Protein-ACE2 Complex and Antibody Evasion","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; University of British Columbia","funders":"University of California, San Francisco; Victoria General Hospital Foundation; Canada Research Chairs; Genome British Columbia; Canadian Institutes of Health Research; Genome Canada","keywords":"Neutralization; Antibody; Chemistry; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Biophysics; Coronavirus disease 2019 (COVID-19); Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122228,0.0002266078,0.0001777018,0.0001096156,0.0002350123,0.0002871323,0.0002488937,0.0003496229,0.001887712],"category_scores_gemma":[0.0002050867,0.000124802,0.0001952555,0.0001632687,0.0001860971,0.0002262011,0.0001760995,0.0006281293,0.0003318188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004605165,"about_ca_system_score_gemma":0.000123899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002415395,"about_ca_topic_score_gemma":0.002012266,"domain_scores_codex":[0.9999503,0.000005828751,0.000002129881,0.00001110326,0.00001658951,0.0000140167],"domain_scores_gemma":[0.9999492,0.00001340687,0.00001116743,0.000005255557,0.000008161202,0.00001274881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000708605,0.000126676,0.007992154,0.0001556406,0.00007880845,0.0009069767,0.0002235715,0.002096376,0.9809069,0.0008342626,0.002507308,0.003462711],"study_design_scores_gemma":[0.0001134604,0.0003845342,0.1831823,0.00005956778,0.00008045191,0.003823082,0.0005552649,0.04411083,0.7534213,0.0009718872,0.01324268,0.00005473822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941329,0.00101234,0.001538092,0.00035044,0.00003426136,0.000006916738,0.0004714301,0.00004745938,0.002406091],"genre_scores_gemma":[0.9942387,0.0004212847,0.001465198,0.0001955614,0.00001382204,0.000007223935,0.001785703,0.00003120054,0.001841128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002415395,"threshold_uncertainty_score":0.006314993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03383235153547445,"score_gpt":0.3084117665813829,"score_spread":0.2745794150459084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}