{"id":"W4200042234","doi":"10.1038/s42004-021-00602-2","title":"Discovering and harnessing oxidative enzymes for chemoenzymatic synthesis and diversification of anticancer camptothecin analogues","year":2021,"lang":"en","type":"article","venue":"Communications Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Stony Brook University; Michael Smith Health Research BC; Canada Foundation for Innovation","keywords":"Camptothecin; Chemistry; Quinoline; Topotecan; Enzyme; Cytochrome P450; Biochemistry; Topoisomerase; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001508475,0.000301378,0.0001472931,0.0001643933,0.0001004898,0.0002633927,0.0002008833,0.0002346313,0.0007815221],"category_scores_gemma":[0.0001278977,0.0001184516,0.0001889691,0.0001720202,0.0002625445,0.0002994578,0.0003039782,0.0005778265,0.0003148237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002730789,"about_ca_system_score_gemma":0.0002248443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003384541,"about_ca_topic_score_gemma":0.0007300218,"domain_scores_codex":[0.9999099,0.00001185118,0.000005470049,0.00002227103,0.0000264126,0.00002408597],"domain_scores_gemma":[0.9999493,0.000007647695,0.00001509664,0.000008386495,0.000007822166,0.00001160175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002694928,0.00002454605,0.0001033297,0.00005258671,0.000005516168,0.0000619047,0.00002203904,0.000273251,0.9924359,0.00113108,0.00008484309,0.005777934],"study_design_scores_gemma":[0.0000115745,0.000154638,0.0004034276,0.000004471067,0.000008679997,0.0001432501,0.00001585417,0.0007079295,0.9919334,0.0002384867,0.006372951,0.000005392659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9298547,0.00503165,0.05390229,0.0005924799,0.00007969479,0.0002026423,0.0004592868,0.0003233618,0.009553936],"genre_scores_gemma":[0.9776866,0.003254396,0.01569153,0.0001052518,0.00001837902,0.00004712882,0.00028085,0.00004107326,0.00287464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007815221,"threshold_uncertainty_score":0.002614498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02831001532177634,"score_gpt":0.285306276153905,"score_spread":0.2569962608321287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}