{"id":"W4200042234","doi":"10.1038/s42004-021-00602-2","title":"Discovering and harnessing oxidative enzymes for chemoenzymatic synthesis and diversification of anticancer camptothecin analogues","year":2021,"lang":"en","type":"article","venue":"Communications Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Stony Brook University; Michael Smith Health Research BC; Canada Foundation for Innovation","keywords":"Camptothecin; Chemistry; Quinoline; Topotecan; Enzyme; Cytochrome P450; Biochemistry; Topoisomerase; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008393086,0.00007637742,0.0001151778,0.000009595709,0.0001107509,0.00002247482,0.0001450297,0.0000560005,0.00000647613],"category_scores_gemma":[0.0001116059,0.00008219414,0.00003238811,0.00004818027,0.0001504366,0.000005831121,0.0002009582,0.00003659676,7.91589e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001079707,"about_ca_system_score_gemma":0.00005284746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008204868,"about_ca_topic_score_gemma":0.00001057978,"domain_scores_codex":[0.9995696,0.00001797574,0.0001262622,0.0001664862,0.00004136984,0.00007831583],"domain_scores_gemma":[0.9991541,0.00007362155,0.00009010071,0.0005520071,0.0001000367,0.00003011772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001199506,0.00003072128,0.0003155485,0.000111804,0.00005645301,5.622015e-8,0.0001415414,0.000001791756,0.9935578,0.0005299338,0.00002163794,0.005220713],"study_design_scores_gemma":[0.0001828522,0.000009123837,0.0005557641,0.0000613095,0.00005618953,0.00000496743,0.0008739543,0.0003149775,0.9949336,0.0002742359,0.002640755,0.00009227298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791591,0.0110404,0.008339076,0.0005559184,0.00001901482,0.0001241786,0.0001169836,0.000007317803,0.0006379657],"genre_scores_gemma":[0.9892152,0.003808648,0.006561041,0.00003589397,0.00002083154,0.00004753202,0.0001309518,0.00001048291,0.0001694172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01005606,"threshold_uncertainty_score":0.335178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02831001532177634,"score_gpt":0.285306276153905,"score_spread":0.2569962608321287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}