{"id":"W4200042237","doi":"10.1016/s1474-4422(21)00367-7","title":"Safety and efficacy of once-daily risdiplam in type 2 and non-ambulant type 3 spinal muscular atrophy (SUNFISH part 2): a phase 3, double-blind, randomised, placebo-controlled trial","year":2021,"lang":"en","type":"letter","venue":"The Lancet Neurology","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":214,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Roche","keywords":"Medicine; Spinal muscular atrophy; Placebo; Clinical endpoint; Physical therapy; Atrophy; Clinical trial; Adverse effect; Internal medicine; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0009094806,0.0004360126,0.00247178,0.0002360495,0.00008447575,0.00003099721,0.0003025772,0.000625297,0.0001234127],"category_scores_gemma":[0.0004854526,0.000302755,0.0002506089,0.0003966089,0.0004812808,0.00002164114,0.0002123453,0.002422496,0.000009941822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000143438,"about_ca_system_score_gemma":0.0004140538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006311744,"about_ca_topic_score_gemma":0.00002162299,"domain_scores_codex":[0.9962327,0.001033004,0.0007684323,0.0007752142,0.0004893857,0.0007012896],"domain_scores_gemma":[0.9978065,0.0007262258,0.0002862863,0.0008735001,0.0001882556,0.0001192437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9708071,0.0002628434,0.00009189146,0.0002704067,0.0004844961,0.002073343,0.00007667146,0.0000114392,0.0004958202,0.000005669513,0.02408824,0.001332128],"study_design_scores_gemma":[0.822603,0.005272024,0.0003276756,0.00007757472,0.000594077,0.0002993116,0.000005917101,0.0001701037,0.00004334157,0.00001187046,0.1704015,0.0001936356],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8696131,0.004284303,0.00001042656,0.1178258,0.0007457702,0.006756581,0.00001710897,0.00002289262,0.0007240006],"genre_scores_gemma":[0.5982782,0.04831429,0.0001270625,0.3325455,0.01627973,0.001079076,0.0009249173,0.0004176904,0.002033551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2713349,"threshold_uncertainty_score":0.9999425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04617068928483851,"score_gpt":0.3368661723032614,"score_spread":0.2906954830184229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}