{"id":"W4200042237","doi":"10.1016/s1474-4422(21)00367-7","title":"Safety and efficacy of once-daily risdiplam in type 2 and non-ambulant type 3 spinal muscular atrophy (SUNFISH part 2): a phase 3, double-blind, randomised, placebo-controlled trial","year":2021,"lang":"en","type":"letter","venue":"The Lancet Neurology","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":214,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Roche","keywords":"Medicine; Spinal muscular atrophy; Placebo; Clinical endpoint; Physical therapy; Atrophy; Clinical trial; Adverse effect; Internal medicine; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001379487,0.001214416,0.003132251,0.000259448,0.0003971887,0.000834928,0.0008889121,0.003962611,0.006698322],"category_scores_gemma":[0.001905837,0.0005166087,0.001881417,0.0002797132,0.0008244264,0.0008690337,0.0002369775,0.003294055,0.001333505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007542202,"about_ca_system_score_gemma":0.0006214574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000799344,"about_ca_topic_score_gemma":0.001724387,"domain_scores_codex":[0.9995933,0.000204341,0.00003268639,0.00007622234,0.00003672563,0.00005674154],"domain_scores_gemma":[0.9991071,0.0003989117,0.0001586033,0.0000447165,0.00007080162,0.0002199005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9640241,0.00216354,0.0004862543,0.001765177,0.001519967,0.0001765704,0.00005167504,0.0001163553,0.002708308,0.00009221495,0.003680432,0.02321532],"study_design_scores_gemma":[0.9637543,0.03195042,0.001812451,0.00009246879,0.0005447032,0.00007212027,0.00002339873,0.0001784274,0.0002536429,0.0001373399,0.001163898,0.00001684014],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9329186,0.04528493,0.0006886034,0.007272238,0.003978093,0.002224902,0.002317054,0.00028932,0.005026355],"genre_scores_gemma":[0.967182,0.009996328,0.001026634,0.01037458,0.001670641,0.002032015,0.001333252,0.00003527147,0.006349176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006698322,"threshold_uncertainty_score":0.02240807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04617068928483851,"score_gpt":0.3368661723032614,"score_spread":0.2906954830184229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}