{"id":"W4200042849","doi":"10.7554/elife.66512.sa2","title":"Author response: External signals regulate continuous transcriptional states in hematopoietic stem cells","year":2021,"lang":"en","type":"peer-review","venue":"","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Stem cell; Biology; Haematopoiesis; Progenitor cell; Cell biology; Chromatin; Population; Hematopoietic stem cell; Immunology; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00333665,0.0004619235,0.0005754144,0.00158347,0.0008792703,0.002790013,0.0008424689,0.001160033,0.1153303],"category_scores_gemma":[0.01516529,0.0002375854,0.0002217011,0.00118009,0.0008234669,0.001542536,0.001545249,0.0009261373,0.05895849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009933028,"about_ca_system_score_gemma":0.002747578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000784667,"about_ca_topic_score_gemma":0.002755508,"domain_scores_codex":[0.9973394,0.0003521334,0.0001311585,0.0002608538,0.001772468,0.0001440459],"domain_scores_gemma":[0.9829718,0.002500563,0.0006658855,0.001014632,0.0108959,0.001951116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007660115,0.00009485324,0.003958101,0.002075214,0.00006054581,0.001267983,0.0007849506,0.0007437122,0.07115609,0.01326744,0.5711496,0.3346754],"study_design_scores_gemma":[0.00003595786,0.00005902724,0.004639433,0.000133454,0.00001696101,0.0003669119,0.0003087719,0.0004064529,0.01697915,0.00283735,0.9741902,0.00002621607],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.1132318,0.03072589,0.03640783,0.09680496,0.1232248,0.002314754,0.01573992,0.005953358,0.5755967],"genre_scores_gemma":[0.1447342,0.01252646,0.009485515,0.003229904,0.01184817,0.0002368344,0.006312812,0.001577992,0.810048],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1153303,"threshold_uncertainty_score":0.3858184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02977468254673245,"score_gpt":0.2839353383114142,"score_spread":0.2541606557646818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}