{"id":"W4200046328","doi":"10.1101/2021.12.02.470965","title":"Contextual control of conditioned pain tolerance and endogenous analgesic systems: Evidence for sex-based differences in endogenous opioid engagement","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Endogenous opioid; Chronic pain; Opioid; Stimulus (psychology); Endogeny; Psychology; Analgesic; Context (archaeology); Neuroscience; Associative learning; Opioid peptide; Medicine; Anesthesia; Cognitive psychology; Internal medicine; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002249035,0.0002611276,0.000295366,0.000393304,0.0001327634,0.0004048329,0.0002130872,0.0002384157,0.003182157],"category_scores_gemma":[0.0002886323,0.0001550147,0.0002400402,0.0001321131,0.0004498734,0.0002695825,0.0003465586,0.0004286281,0.0002557693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001672198,"about_ca_system_score_gemma":0.0001317726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002925589,"about_ca_topic_score_gemma":0.0004018909,"domain_scores_codex":[0.999795,0.00002542597,0.00001231719,0.00006237788,0.00005758381,0.0000474109],"domain_scores_gemma":[0.9996033,0.0000414776,0.000183578,0.00005281855,0.0000286684,0.00009002629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000416321,0.00005982124,0.001972667,0.00004929248,0.00001425721,0.0000975994,0.00004820116,0.00002756724,0.9925767,0.0004539794,0.00006369079,0.004220096],"study_design_scores_gemma":[0.00007163906,0.001243483,0.2660198,0.00004733427,0.00007847306,0.001339812,0.0001768246,0.0008027081,0.7254438,0.001173966,0.003556184,0.00004606682],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916135,0.002685812,0.003131266,0.0001946432,0.00005835702,0.0000138813,0.0005283016,0.00005420105,0.001720075],"genre_scores_gemma":[0.9942915,0.0012045,0.0014325,0.0001312015,0.00003295292,0.0000385126,0.0003043425,0.00004630583,0.002518136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003182157,"threshold_uncertainty_score":0.01064533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07046226007127472,"score_gpt":0.2588565897960018,"score_spread":0.1883943297247271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}