{"id":"W4200048265","doi":"10.1158/1535-7163.targ-21-p058","title":"Abstract P058: Anti-tumor activity of ATR inhibitor BAY 1895344 in patient-derived xenograft (PDX) models with DNA damage response (DDR) pathway alterations","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Weyerhauser (Canada)","funders":"","keywords":"In vivo; Medicine; Cancer research; Immunohistochemistry; Cancer; DNA damage; Internal medicine; Oncology; Pathology; Biology; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002474026,0.0004693837,0.0004064357,0.0002644579,0.0001265134,0.0002284389,0.0002627321,0.0002897412,0.002353719],"category_scores_gemma":[0.00009637212,0.0001222853,0.000267619,0.0002143003,0.0001379774,0.0002587432,0.0001248044,0.001044127,0.0004868059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002312649,"about_ca_system_score_gemma":0.0002458542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005341646,"about_ca_topic_score_gemma":0.0006925783,"domain_scores_codex":[0.9998575,0.0000296688,0.0000167364,0.00003271087,0.00003251768,0.00003086956],"domain_scores_gemma":[0.9998819,0.00002565984,0.00002639456,0.00001994274,0.00001160348,0.00003459805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001883476,0.001598148,0.0007564168,0.0001176997,0.00002960904,0.000103373,0.00002477862,0.000558834,0.9879805,0.0001472297,0.0006207872,0.006179119],"study_design_scores_gemma":[0.0002578344,0.01378378,0.006328531,0.000007555365,0.00005636396,0.0004849729,0.00002835282,0.002587645,0.9743893,0.00004217824,0.002027014,0.000006407888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949485,0.0007399263,0.001447097,0.00009685832,0.0000584571,0.00008551688,0.001348812,0.0001295906,0.001145199],"genre_scores_gemma":[0.992408,0.0006933507,0.002218321,0.00004410701,0.00001707759,0.0001059633,0.002172779,0.00002106982,0.002319364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002353719,"threshold_uncertainty_score":0.007874012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02152725350841482,"score_gpt":0.2600220771626779,"score_spread":0.2384948236542631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}