{"id":"W4200048265","doi":"10.1158/1535-7163.targ-21-p058","title":"Abstract P058: Anti-tumor activity of ATR inhibitor BAY 1895344 in patient-derived xenograft (PDX) models with DNA damage response (DDR) pathway alterations","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Weyerhauser (Canada)","funders":"","keywords":"In vivo; Medicine; Cancer research; Immunohistochemistry; Cancer; DNA damage; Internal medicine; Oncology; Pathology; Biology; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002186354,0.0003192663,0.0003305568,0.00008682358,0.00009362733,0.00005015035,0.0001985883,0.0001829823,0.00004326778],"category_scores_gemma":[0.00002856304,0.0003092138,0.0001496906,0.0002920828,0.0001385131,0.0000210706,0.0001175103,0.0002451786,0.000002101824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005444032,"about_ca_system_score_gemma":0.000663926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004836618,"about_ca_topic_score_gemma":0.0003031898,"domain_scores_codex":[0.9980541,0.000330378,0.0003586841,0.0005478067,0.0003044685,0.0004045467],"domain_scores_gemma":[0.9987133,0.00003540636,0.0002152807,0.0006725563,0.0002562529,0.0001072219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009155681,0.0003010204,0.0004181997,0.000059284,0.0001507261,0.0001734034,0.0004353533,0.002420095,0.992173,0.00004523416,0.00001305089,0.002895065],"study_design_scores_gemma":[0.001149834,0.0004067082,0.001967297,0.0001104068,0.00003909815,0.00001821089,0.0001306914,0.000503031,0.9919297,0.00007671191,0.003289344,0.0003790366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992685,0.00192382,0.003927604,0.0003619796,0.0001064876,0.0004275124,0.0002581193,0.00001966484,0.0002898595],"genre_scores_gemma":[0.9976755,0.0002058669,0.0009328636,0.0007994093,0.00006070711,0.0001130583,0.0000956207,0.00006917061,0.00004776746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004990583,"threshold_uncertainty_score":0.999936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02152725350841482,"score_gpt":0.2600220771626779,"score_spread":0.2384948236542631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}