{"id":"W4200048325","doi":"10.3390/cells10123464","title":"The Role of Chaperone-Mediated Autophagy in Bortezomib Resistant Multiple Myeloma","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Bortezomib; Cell culture; Downregulation and upregulation; Flow cytometry; Apoptosis; Blot; Autophagy; Molecular biology; Programmed cell death; Cancer research; Chemistry; Biology; Multiple myeloma; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002331145,0.0002583855,0.0003164197,0.000399074,0.0002381472,0.0003907247,0.000126819,0.0003422667,0.0006494212],"category_scores_gemma":[0.000150254,0.0001159454,0.0002627694,0.0003050702,0.0001792176,0.0001792314,0.0002047855,0.0002743341,0.0001656864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003280412,"about_ca_system_score_gemma":0.0001716997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003510028,"about_ca_topic_score_gemma":0.0004025717,"domain_scores_codex":[0.9999001,0.00002077152,0.00001410964,0.00001774755,0.0000301607,0.00001710087],"domain_scores_gemma":[0.9999027,0.00001010764,0.00004812469,0.000007536622,0.00001529401,0.00001625467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00135869,0.0001418173,0.02061964,0.0007076241,0.000101562,0.001463071,0.0001364976,0.0005333333,0.9551461,0.0002789341,0.0006315526,0.01888119],"study_design_scores_gemma":[0.0001909662,0.002963967,0.5148003,0.0002255582,0.0004136423,0.02060488,0.0004957453,0.006232095,0.4223312,0.001050145,0.03063781,0.00005380354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708492,0.0266905,0.0009205915,0.0002131075,0.00003195273,0.00002619844,0.0002973774,0.00007069762,0.0009004672],"genre_scores_gemma":[0.9935483,0.005220808,0.000462798,0.00005767516,0.00002343947,0.00001498775,0.0002570071,0.000006692474,0.0004082761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006494212,"threshold_uncertainty_score":0.002380073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.012029000831436,"score_gpt":0.2614269696367979,"score_spread":0.2493979688053619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}