{"id":"W4200052017","doi":"10.26434/chemrxiv-2021-gfqrl","title":"Computational Insights in DNA Methylation: Catalytic and Mechanistic Elucidations","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"University of Jordan; Compute Canada","keywords":"DNA methylation; Epigenetics; Methyltransferase; Methylation; CpG site; DNA; Biology; Cytosine; Genetics; Computational biology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007161048,0.000966361,0.001589307,0.0007426058,0.0009960552,0.001359859,0.001879364,0.00248126,0.006163635],"category_scores_gemma":[0.00194406,0.0005695392,0.001188894,0.000815373,0.001045597,0.001462414,0.001025848,0.001349024,0.000692949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001038447,"about_ca_system_score_gemma":0.001574131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007392055,"about_ca_topic_score_gemma":0.005182453,"domain_scores_codex":[0.999744,0.00008739301,0.000009137286,0.00003221713,0.00006559044,0.0000616325],"domain_scores_gemma":[0.9994104,0.000374174,0.00003014737,0.00007212768,0.00006708238,0.00004609515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001033969,0.0001129916,0.001035715,0.0003447942,0.00006553649,0.0002223203,0.00009617562,0.8788759,0.001599598,0.1085217,0.001960441,0.007061406],"study_design_scores_gemma":[0.00002943053,0.00001895169,0.0001570498,0.00001614599,0.00001233055,0.0000189598,0.00003134616,0.9757751,0.0002324417,0.02247786,0.001221802,0.000008500854],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5301265,0.007861429,0.2996069,0.01009989,0.0007874356,0.0002417534,0.004079832,0.001077448,0.1461188],"genre_scores_gemma":[0.9401137,0.002434053,0.04850622,0.0006913695,0.0001767355,0.0004867693,0.001433686,0.000258725,0.005898774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007392055,"threshold_uncertainty_score":0.02061939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01742788548022777,"score_gpt":0.2681105122629778,"score_spread":0.25068262678275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}