{"id":"W4200053736","doi":"10.1016/s2152-2650(21)01829-2","title":"MPN-303: Longitudinal and Individual Symptom Analyses from the SIMPLIFY-1 Study Demonstrate Clinically Comparable Symptomatic Benefit of Momelotinib to Ruxolitinib in JAK Inhibitor-Naive Myelofibrosis Patients","year":2021,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital; University of Toronto; University of British Columbia; University Health Network","funders":"","keywords":"Ruxolitinib; Myelofibrosis; Medicine; Internal medicine; Longitudinal study; Oncology; Pathology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001290861,0.0003217919,0.0008609926,0.0002048463,0.0002578021,0.0006502341,0.0002980866,0.0003624923,0.001335912],"category_scores_gemma":[0.001920009,0.0001580228,0.0008510047,0.00028232,0.0002337517,0.0004444153,0.0003026146,0.0007183943,0.000207118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003469725,"about_ca_system_score_gemma":0.0004245449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001203077,"about_ca_topic_score_gemma":0.003720867,"domain_scores_codex":[0.999592,0.0001610043,0.00003323437,0.00008767856,0.00006530685,0.00006079911],"domain_scores_gemma":[0.9991108,0.0002414204,0.0002850993,0.0001331249,0.00005683961,0.0001727463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1594598,0.002810635,0.6256933,0.0004354556,0.004685265,0.0005646544,0.0003100327,0.001860308,0.02809606,0.0003283141,0.005041952,0.1707142],"study_design_scores_gemma":[0.004564619,0.006772779,0.9834363,0.00002169901,0.0009561899,0.0004603687,0.00006983722,0.0007945003,0.001347466,0.0001421867,0.001405354,0.00002853476],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974675,0.0008158069,0.0001016042,0.000103259,0.000009929774,0.00002163217,0.0008236875,0.00001824029,0.0006381541],"genre_scores_gemma":[0.9975617,0.0002034525,0.0001438002,0.00009311971,0.00002865775,0.00001502572,0.001739781,0.000006340847,0.000208144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001335912,"threshold_uncertainty_score":0.006826818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08829957035055626,"score_gpt":0.3818298745004986,"score_spread":0.2935303041499424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}