{"id":"W4200066026","doi":"10.3899/jrheum.211155","title":"Off-label Use of Secukinumab: A Potential Therapeutic Option for SAPHO Syndrome","year":2021,"lang":"en","type":"letter","venue":"The Journal of Rheumatology","topic":"Osteomyelitis and Bone Disorders Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"SAPHO syndrome; Medicine; Secukinumab; Pustulosis; Dermatology; Synovitis; Hyperostosis; Rheumatology; Osteitis; Acne; Internal medicine; Psoriatic arthritis; Surgery; Arthritis; Psoriasis; Osteomyelitis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001300074,0.0007384318,0.001183877,0.0006058479,0.001317017,0.001519106,0.001331395,0.01433034,0.0022941],"category_scores_gemma":[0.009490114,0.0004185185,0.0007158942,0.0004719657,0.001249077,0.002372055,0.0005853954,0.01317338,0.001866184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001448287,"about_ca_system_score_gemma":0.0007363205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006714883,"about_ca_topic_score_gemma":0.001092634,"domain_scores_codex":[0.9989564,0.0003887028,0.0001631163,0.0001342704,0.0002139594,0.00014339],"domain_scores_gemma":[0.9972308,0.001408502,0.0002967441,0.00007132591,0.0005352382,0.0004573772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"case_report","study_design_scores_codex":[0.0003875528,0.0001470433,0.00470777,0.0003853821,0.0001080943,0.0779761,0.0003063301,0.0002680788,0.001034451,0.002920937,0.8711233,0.04063504],"study_design_scores_gemma":[0.000708506,0.0005052235,0.006462114,0.001011791,0.0002617383,0.2099342,0.000830713,0.003490653,0.00206102,0.009301145,0.7652691,0.0001638265],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.006312374,0.01367901,0.0005472206,0.9267294,0.04987617,0.00002199588,0.00008398362,0.0000874349,0.002662458],"genre_scores_gemma":[0.05452635,0.01288078,0.0007342884,0.6392627,0.2862255,0.00004529088,0.0000908935,0.00005331783,0.006180873],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01433034,"threshold_uncertainty_score":0.01050812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05297016225343046,"score_gpt":0.3090664781784297,"score_spread":0.2560963159249993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}