{"id":"W4200068599","doi":"10.1126/sciadv.abg6363","title":"Chromatin architecture at susceptible gene loci in cerebellar Purkinje cells characterizes DNA damage–induced neurodegeneration","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute","keywords":"Neurodegeneration; Biology; Genome instability; Ataxia; DNA damage; RNA splicing; Gene; Cerebellum; Chromatin; Purkinje cell; Genetics; Neuroscience; Cell biology; RNA; DNA; Disease; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002696202,0.0003414236,0.0002994899,0.0002855159,0.0006648244,0.0002911116,0.0008061885,0.00005324503,0.0002108793],"category_scores_gemma":[0.0007784473,0.000323994,0.00008278724,0.002176055,0.0006625607,0.0008638444,0.0004149141,0.0002131184,0.0001272014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001327915,"about_ca_system_score_gemma":0.0004322849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007033082,"about_ca_topic_score_gemma":0.0001587504,"domain_scores_codex":[0.9958411,0.0003632871,0.0004218254,0.001586906,0.0009812047,0.0008056088],"domain_scores_gemma":[0.9985106,0.000149365,0.0002026397,0.0007404225,0.0001454225,0.000251556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001635763,0.0001012458,0.0008699643,0.00002136962,6.426713e-7,0.00008562688,0.000268321,0.003441705,0.99248,0.00005369566,0.00002322203,0.002637808],"study_design_scores_gemma":[0.0003316034,0.0001291734,0.009252037,0.00001807657,0.000005570112,0.00002994638,0.00006578182,0.0003907266,0.9882997,0.0001769867,0.0009582231,0.0003421232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971575,0.0001951363,0.0001177056,0.0006223088,0.0008761327,0.0003716061,0.0000512104,0.00008530549,0.0005231522],"genre_scores_gemma":[0.9966398,0.0001251581,0.001173726,0.00122507,0.000149503,0.00004154509,0.00001607506,0.00003184818,0.0005972381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008382073,"threshold_uncertainty_score":0.9999212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02056644547851122,"score_gpt":0.2674503934750594,"score_spread":0.2468839479965482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}