{"id":"W4200068599","doi":"10.1126/sciadv.abg6363","title":"Chromatin architecture at susceptible gene loci in cerebellar Purkinje cells characterizes DNA damage–induced neurodegeneration","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute","keywords":"Neurodegeneration; Biology; Genome instability; Ataxia; DNA damage; RNA splicing; Gene; Cerebellum; Chromatin; Purkinje cell; Genetics; Neuroscience; Cell biology; RNA; DNA; Disease; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001038711,0.0001507879,0.000146538,0.0004337489,0.0001376519,0.0002697344,0.0001259244,0.0001765782,0.001749952],"category_scores_gemma":[0.0002057579,0.0001600515,0.0001277074,0.0002389458,0.0002990727,0.0001537007,0.0002051553,0.0002323762,0.000292052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001790916,"about_ca_system_score_gemma":0.0001024841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006294301,"about_ca_topic_score_gemma":0.002616744,"domain_scores_codex":[0.9999027,0.000007287677,0.000005740509,0.00004642508,0.00002229761,0.00001551123],"domain_scores_gemma":[0.9997982,0.00002197509,0.00009107163,0.0000287386,0.00002015206,0.00003983147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006692185,0.000008195359,0.007140101,0.00003789593,0.00002629487,0.0001127657,0.00006794013,0.0001964515,0.9898742,0.0001033677,0.00005133685,0.00231444],"study_design_scores_gemma":[0.00001508776,0.0002711576,0.6133166,0.00001879081,0.00008596207,0.001944481,0.0002300897,0.002334056,0.378341,0.0007836598,0.002638526,0.00002061884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929478,0.0008418494,0.004422943,0.00003279337,0.000009466818,0.00001247582,0.0005554548,0.00008822115,0.001088946],"genre_scores_gemma":[0.9981766,0.00017459,0.0006321801,0.00002050618,0.000003171429,0.00000735073,0.0003194902,0.0000106786,0.000655428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001749952,"threshold_uncertainty_score":0.005854189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02056644547851122,"score_gpt":0.2674503934750594,"score_spread":0.2468839479965482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}