{"id":"W4200069316","doi":"10.1158/1078-0432.ccr-21-3032","title":"Updated Overall Survival of Ribociclib plus Endocrine Therapy versus Endocrine Therapy Alone in Pre- and Perimenopausal Patients with HR+/HER2− Advanced Breast Cancer in MONALEESA-7: A Phase III Randomized Clinical Trial","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":263,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute; Novartis Institutes for BioMedical Research; Astex Pharmaceuticals; Novartis Pharmaceuticals Corporation","keywords":"Overall survival; Randomized controlled trial; Endocrine system; Clinical trial; Breast cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004591967,0.0005935685,0.003676051,0.0003670712,0.0001067768,0.00004609111,0.0004113522,0.0002744882,0.001461527],"category_scores_gemma":[0.001145524,0.0004498555,0.0003635328,0.00120262,0.002015034,0.0003422457,0.0002796125,0.002305078,0.000002868921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006053504,"about_ca_system_score_gemma":0.00287704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00319495,"about_ca_topic_score_gemma":0.002516824,"domain_scores_codex":[0.988948,0.003527741,0.002920198,0.001571729,0.001756671,0.001275609],"domain_scores_gemma":[0.9914144,0.005003305,0.0005807471,0.0009530833,0.001462678,0.0005857337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8002751,0.005246344,0.05308923,0.00005888161,0.0008418174,0.0002322805,0.000283044,0.0001017073,0.000923507,0.00005458034,0.00003236589,0.1388611],"study_design_scores_gemma":[0.858683,0.006350848,0.130488,0.0004156159,0.00007067424,0.00001179383,0.0001264623,0.0002528024,0.0008577271,0.0001024411,0.002246435,0.0003941558],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795967,0.011445,0.00001893184,0.002413739,0.0009308771,0.005080567,0.0003406804,0.00005271441,0.0001207459],"genre_scores_gemma":[0.9586929,0.03761403,0.0003313125,0.0003170473,0.0008100839,0.001509141,0.0001765014,0.0001313783,0.0004175887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.138467,"threshold_uncertainty_score":0.9999967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.127275101733424,"score_gpt":0.5170188085085538,"score_spread":0.3897437067751297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}