{"id":"W4200069835","doi":"10.1038/s41591-021-01574-5","title":"A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques","year":2021,"lang":"en","type":"article","venue":"Nature Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":165,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"NHLBI Division of Intramural Research; Vaccine Research Center; Office of AIDS Research; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Frederick National Laboratory for Cancer Research; National Institutes of Health; Universiteit van Amsterdam; U.S. Department of Health and Human Services","keywords":"Virology; Heterologous; Simian immunodeficiency virus; Antibody; Biology; Neutralizing antibody; Virus; Neutralization; Gp41; HIV vaccine; AIDS Vaccines; Glycan; Vaccination; Immunology; Glycoprotein; Vaccine trial; Gene; Epitope; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893096,0.000316842,0.0002365694,0.0002377463,0.00019104,0.0003048152,0.0002295559,0.0005530966,0.001354209],"category_scores_gemma":[0.0002177808,0.0001269169,0.00017171,0.00005385551,0.0002531646,0.0002123183,0.0001607258,0.0007056469,0.0002393436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003624235,"about_ca_system_score_gemma":0.0002327323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00150966,"about_ca_topic_score_gemma":0.002248749,"domain_scores_codex":[0.9998647,0.00001619978,0.000005969732,0.00003309628,0.0000208019,0.00005913006],"domain_scores_gemma":[0.9998665,0.00002348324,0.00002865015,0.00001754053,0.00002042681,0.0000435406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006548307,0.0004231662,0.0006708631,0.00003556338,0.00001243115,0.00004516518,0.00004304992,0.0001697506,0.9938753,0.0001269178,0.000171013,0.003771933],"study_design_scores_gemma":[0.0003376841,0.01589474,0.02432677,0.00003127,0.00009311152,0.0008423803,0.0002245712,0.004510582,0.9492465,0.0002643167,0.004205097,0.00002295326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991577,0.00009991784,0.0003364175,0.00005472749,0.00001847892,0.00001114883,0.00004516894,0.00002094462,0.0002554856],"genre_scores_gemma":[0.9975085,0.0001114214,0.0005961382,0.00007374051,0.00001531163,0.00001801668,0.0001577217,0.000008004728,0.001511045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00150966,"threshold_uncertainty_score":0.004530311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009718197827999328,"score_gpt":0.2904454997583891,"score_spread":0.2807273019303897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}