{"id":"W4200071447","doi":"10.1038/s41586-021-04177-9","title":"Combinatorial, additive and dose-dependent drug–microbiome associations","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":237,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"H2020 European Research Council; Institut de Cardiométabolisme et Nutrition; NIHR Imperial Biomedical Research Centre; Conseil Régional Hauts-de-France; Assistance publique-Hôpitaux de Paris; Horizon 2020 Framework Programme; Novo Nordisk Fonden; Medical Research Council; Novo Nordisk Foundation Center for Basic Metabolic Research; Julius-Maximilians-Universität Würzburg; Institut National de la Santé et de la Recherche Médicale; Eli Lilly and Company; Lundbeckfonden; Yonsei University; Sanofi; Danone; European Commission; Helmholtz Zentrum München; Novo Nordisk; National Institute for Health and Care Research; CHIST-ERA; Agence Nationale de la Recherche; AstraZeneca; Deutsche Forschungsgemeinschaft","keywords":"Microbiome; Drug; Computational biology; Biology; Pharmacology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000474157,0.0004446339,0.0008035069,0.0005275186,0.0001862135,0.0008364752,0.0005036007,0.0005981774,0.005240678],"category_scores_gemma":[0.001026506,0.0003974534,0.0004929493,0.0003706038,0.0004247032,0.0004028516,0.0006596473,0.000873022,0.0006513576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000400373,"about_ca_system_score_gemma":0.0004473781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005159056,"about_ca_topic_score_gemma":0.002071957,"domain_scores_codex":[0.9994264,0.0001377385,0.00004810827,0.0001423845,0.0001598796,0.00008549752],"domain_scores_gemma":[0.9990193,0.0003449817,0.0001662849,0.000218449,0.00009052885,0.000160563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004526288,0.0008701021,0.005846606,0.0003490748,0.000374137,0.0001375549,0.00005170603,0.001445053,0.9560347,0.0008984673,0.0008344175,0.02863183],"study_design_scores_gemma":[0.0003449425,0.01051908,0.05788778,0.00005069021,0.001325389,0.001142683,0.0001838847,0.007527623,0.9037164,0.001680845,0.01549364,0.0001268688],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830451,0.003057384,0.006143981,0.0003973102,0.0002621178,0.0001548539,0.002269922,0.0003452856,0.004323959],"genre_scores_gemma":[0.9886258,0.00119707,0.004661894,0.000262111,0.00003804348,0.0001279255,0.0006353642,0.00005436738,0.004397465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005240678,"threshold_uncertainty_score":0.01753181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004059130799516636,"score_gpt":0.257868676604767,"score_spread":0.2538095458052504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}