{"id":"W4200077534","doi":"10.1080/14756366.2021.1994559","title":"Heterologous expression and biochemical characterisation of the recombinant β-carbonic anhydrase (MpaCA) from the warm-blooded vertebrate pathogen <i>malassezia pachydermatis</i>","year":2021,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"Fondazione Cassa di Risparmio di Firenze; Ente Cassa di Risparmio di Firenze","keywords":"Microbiology; Biology; Malassezia; Antifungal drug; Virulence; Heterologous expression; Fungus; Candida albicans; Recombinant DNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002408977,0.0001449254,0.000205272,0.00001357908,0.00009320521,0.0000220018,0.00007430307,0.0001882072,0.00004652179],"category_scores_gemma":[0.000255905,0.00009003482,0.0001060522,0.00007213555,0.000170486,0.00001883506,0.00008775648,0.0002905994,2.596334e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001577736,"about_ca_system_score_gemma":0.0001013786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003967601,"about_ca_topic_score_gemma":0.000002787588,"domain_scores_codex":[0.9988794,0.0001191502,0.0004418015,0.0001891061,0.0002410986,0.0001294835],"domain_scores_gemma":[0.999014,0.00004240777,0.0004451653,0.0002011163,0.0001871666,0.0001102017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001321303,0.00009205603,0.001348996,0.00003825028,0.00002710658,0.00001290257,0.0001039111,0.000001253046,0.9915621,0.000001848846,0.006431112,0.0002483776],"study_design_scores_gemma":[0.001442272,0.0001232881,0.003728738,0.0003636307,0.00007445055,0.0006437741,0.0004217965,0.00003620546,0.9908614,0.00009438197,0.002114842,0.00009522356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946579,0.002998004,0.0000932922,0.001837455,0.000215291,0.0000632259,0.00004990794,0.000003524413,0.00008144052],"genre_scores_gemma":[0.9970372,0.00113956,0.0000625227,0.00110078,0.0004014524,0.000002927615,0.0001782491,0.00001074805,0.00006658465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00431627,"threshold_uncertainty_score":0.3671513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00592953314296141,"score_gpt":0.2008406035671567,"score_spread":0.1949110704241953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}