{"id":"W4200077534","doi":"10.1080/14756366.2021.1994559","title":"Heterologous expression and biochemical characterisation of the recombinant β-carbonic anhydrase (MpaCA) from the warm-blooded vertebrate pathogen <i>malassezia pachydermatis</i>","year":2021,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"Fondazione Cassa di Risparmio di Firenze; Ente Cassa di Risparmio di Firenze","keywords":"Microbiology; Biology; Malassezia; Antifungal drug; Virulence; Heterologous expression; Fungus; Candida albicans; Recombinant DNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002015338,0.0003780393,0.0003075193,0.0001741684,0.0001622319,0.0003571344,0.0002635125,0.0003091608,0.0005326254],"category_scores_gemma":[0.0003165377,0.0001202715,0.0004478342,0.0003648353,0.0002145649,0.000257336,0.0002218179,0.0005483755,0.0005147515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003941134,"about_ca_system_score_gemma":0.0003177886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00277978,"about_ca_topic_score_gemma":0.002072253,"domain_scores_codex":[0.9998235,0.0000206942,0.00002198204,0.00004153876,0.00006095167,0.00003148761],"domain_scores_gemma":[0.9998454,0.00003041389,0.000043827,0.00002094099,0.00003405856,0.00002532208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002445404,0.00001523407,0.0002381613,0.00005458379,0.000005125113,0.00004946839,0.00002111291,0.00008400144,0.9982262,0.0001160241,0.00005234075,0.001113297],"study_design_scores_gemma":[0.00001084084,0.000124442,0.006858074,0.00001122252,0.0000283351,0.0006775764,0.00005078851,0.0009363068,0.9771237,0.00006393457,0.01410571,0.000009162709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677326,0.004899896,0.01846256,0.0006893128,0.0001398324,0.000207343,0.00398603,0.000208254,0.003674175],"genre_scores_gemma":[0.9533327,0.00329793,0.02557116,0.0001345238,0.00005670907,0.00007766802,0.01083617,0.00008167252,0.00661151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00277978,"threshold_uncertainty_score":0.005527198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00592953314296141,"score_gpt":0.2008406035671567,"score_spread":0.1949110704241953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}