{"id":"W4200082979","doi":"10.1038/s41379-021-00998-1","title":"Expanding the clinicopathological spectrum of succinate dehydrogenase-deficient renal cell carcinoma with a focus on variant morphologies: a study of 62 new tumors in 59 patients","year":2021,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; McGill University; Calgary Laboratory Services; McMaster University","funders":"","keywords":"Pathology; Renal cell carcinoma; SDHB; Eosinophilic; Immunohistochemistry; SDHA; Grading (engineering); Medicine; Clear cell; Biology; Succinate dehydrogenase; Germline mutation; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004858268,0.000317075,0.0005168521,0.001619119,0.0007063326,0.0007069407,0.0003116757,0.000337509,0.001187683],"category_scores_gemma":[0.001367677,0.0003187988,0.0003908415,0.001274024,0.000563987,0.0006954565,0.0008670184,0.0003123325,0.0003169288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002003658,"about_ca_system_score_gemma":0.000307325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001241007,"about_ca_topic_score_gemma":0.001602849,"domain_scores_codex":[0.999445,0.00007436882,0.00007109654,0.000180501,0.000107675,0.0001212453],"domain_scores_gemma":[0.9993452,0.0002005615,0.0001293561,0.00008776348,0.00008638454,0.0001506435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001720386,0.00004671798,0.9885719,0.00001341901,0.00002269081,0.00298393,0.0002795199,0.00005210684,0.002267187,0.00004215372,0.00005468666,0.005493574],"study_design_scores_gemma":[0.00001018915,0.0001257261,0.9825424,0.000009474332,0.00005311347,0.01497425,0.0007621506,0.0002436869,0.0004361868,0.00006502636,0.0007677005,0.00001023827],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987689,0.000473337,0.0002256718,0.00001120252,0.000004336795,0.000008231163,0.00006200183,0.000002689176,0.0004437499],"genre_scores_gemma":[0.9994331,0.0002136167,0.0001229852,0.00001223792,0.00001193591,0.000004745681,0.0001113849,0.0000027728,0.00008719304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001619119,"threshold_uncertainty_score":0.003973186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03069501018092873,"score_gpt":0.2649943465478186,"score_spread":0.2342993363668899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}