{"id":"W4200084953","doi":"10.1089/vim.2021.0071","title":"<i>Interleukin-1</i> in COVID-19 Infection: Immunopathogenesis and Possible Therapeutic Perspective","year":2021,"lang":"en","type":"review","venue":"Viral Immunology","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Cytokine storm; Immunology; Medicine; Pneumonia; Immune system; Coronavirus; Cytokine; Cytokine release syndrome; Disease; Inflammation; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Immunotherapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008215134,0.0005795524,0.003277522,0.000751649,0.0001718127,0.0000599809,0.0002419347,0.0007022299,0.0002625644],"category_scores_gemma":[0.01295692,0.0004633472,0.0006767006,0.0009781691,0.0008070956,0.00009904152,0.0007660622,0.001598836,0.00009776409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002081547,"about_ca_system_score_gemma":0.003137346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00203051,"about_ca_topic_score_gemma":0.0001354018,"domain_scores_codex":[0.9959701,0.001102563,0.0009518171,0.001042304,0.0002650011,0.0006682263],"domain_scores_gemma":[0.9941887,0.004286604,0.0002734009,0.0008064576,0.000243115,0.0002017081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002188982,0.000414908,0.0005800847,0.01042074,0.00193444,0.001004319,0.0003926333,5.801429e-7,0.00008523289,0.001291083,0.000103748,0.9835533],"study_design_scores_gemma":[0.001588414,0.001017724,0.0007371288,0.005999088,0.0008665722,0.0002870197,0.0001934051,0.000002350063,0.000004700924,0.0004048934,0.988511,0.0003876747],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001714928,0.9954495,0.00005544612,0.00222662,0.0003608508,0.001196149,0.00002792361,0.00009177245,0.0004202134],"genre_scores_gemma":[0.0004732343,0.9958152,0.00004212001,0.001923473,0.0001343797,0.0004042241,0.0000521375,0.00007015632,0.001085114],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9884073,"threshold_uncertainty_score":0.9997818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09173521946107836,"score_gpt":0.475754173604636,"score_spread":0.3840189541435576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}