{"id":"W4200086372","doi":"10.3389/fmicb.2021.803309","title":"Dioctanoyl Ultrashort Tetrabasic β-Peptides Sensitize Multidrug-Resistant Gram-Negative Bacteria to Novobiocin and Rifampicin","year":2021,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Novobiocin; Enterobacter cloacae; Microbiology; Rifampicin; Gram-negative bacteria; Acinetobacter baumannii; Biology; Moxalactam; Pseudomonas aeruginosa; Bacteria; Multiple drug resistance; Escherichia coli; Antibiotics; Enterobacteriaceae; Chemistry; Biochemistry; Cephalosporin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008975223,0.0002440422,0.0001576461,0.00008304113,0.00005032615,0.0001279303,0.0001042446,0.0001588021,0.0006786492],"category_scores_gemma":[0.0001283164,0.0001045905,0.00009752875,0.00006947419,0.0001390773,0.0001239151,0.0001047634,0.0003205417,0.0001242928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001083491,"about_ca_system_score_gemma":0.0001087832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001791902,"about_ca_topic_score_gemma":0.0004271751,"domain_scores_codex":[0.9999346,0.00001203622,0.00000772381,0.00001347716,0.00001693104,0.00001525961],"domain_scores_gemma":[0.9999052,0.00001668782,0.00003986468,0.000006373832,0.000008838815,0.0000231032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006864525,0.00001151596,0.00006407118,0.00001521138,0.000001876128,0.00001860443,0.00000508867,0.0000357073,0.9989913,0.00001563064,0.000005619649,0.0007667201],"study_design_scores_gemma":[0.00001744014,0.0004394987,0.001287904,0.000002128,0.00000450239,0.0001177003,0.000008510286,0.0001926151,0.997346,0.00001147547,0.0005696487,0.000002535661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978945,0.000498797,0.0009361958,0.00002713426,0.000009866706,0.00001955589,0.00005479494,0.00001280493,0.0005463221],"genre_scores_gemma":[0.9961758,0.0004876712,0.002220161,0.00004440098,0.000004833367,0.00001689984,0.00009383602,0.000007640897,0.0009487072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006786492,"threshold_uncertainty_score":0.002270341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004855900593167167,"score_gpt":0.2192238471401655,"score_spread":0.2143679465469984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}