{"id":"W4200087363","doi":"10.1358/dot.2021.57.12.3352740","title":"Casimersen for Duchenne muscular dystrophy","year":2021,"lang":"en","type":"article","venue":"Drugs of today","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"","keywords":"Medicine; Exon skipping; Duchenne muscular dystrophy; Dystrophin; Exon; Muscular dystrophy; Population; Antisense therapy; Bioinformatics; Clinical trial; Pharmacology; Internal medicine; Genetics; Gene; Oligonucleotide; Biology; Alternative splicing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006570451,0.00008073893,0.0001203258,0.00001381792,0.0000385471,0.000003376545,0.00008964989,0.00009782893,0.00004480535],"category_scores_gemma":[0.00008801068,0.00008066053,0.0001450117,0.00003995994,0.0000586123,0.000001663118,0.00005269769,0.00003072192,0.000004248904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002534623,"about_ca_system_score_gemma":0.00005936273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001236225,"about_ca_topic_score_gemma":0.000006624639,"domain_scores_codex":[0.9994482,0.0000274978,0.0001156084,0.0002172712,0.00004555401,0.0001458569],"domain_scores_gemma":[0.9995272,0.00001377031,0.00004510764,0.0002670162,0.0001089166,0.00003800124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001137164,0.00007725123,0.0001444128,0.00004499442,0.0000947691,0.000001711772,0.00005683845,0.00007612749,0.9918413,0.0007627495,0.00443444,0.002351737],"study_design_scores_gemma":[0.001068667,0.0001938405,0.001253632,0.000008354922,0.00003792848,0.000003529422,0.0003543584,0.00002635265,0.8682781,0.0009424887,0.1276564,0.0001762591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995238,0.0009572222,0.000739439,0.0003479046,0.0001566429,0.0001046776,0.00003998676,0.000005603307,0.002410497],"genre_scores_gemma":[0.9974068,0.00006989207,0.001208558,0.0002650451,0.0001102947,0.0000185226,0.0002396023,0.00001163959,0.0006696613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1235631,"threshold_uncertainty_score":0.3289241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005900815163805081,"score_gpt":0.2427122663161498,"score_spread":0.2368114511523448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}