{"id":"W4200087363","doi":"10.1358/dot.2021.57.12.3352740","title":"Casimersen for Duchenne muscular dystrophy","year":2021,"lang":"en","type":"article","venue":"Drugs of today","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"","keywords":"Medicine; Exon skipping; Duchenne muscular dystrophy; Dystrophin; Exon; Muscular dystrophy; Population; Antisense therapy; Bioinformatics; Clinical trial; Pharmacology; Internal medicine; Genetics; Gene; Oligonucleotide; Biology; Alternative splicing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007494143,0.0010492,0.0006615291,0.001114029,0.000638939,0.0007730316,0.0005718856,0.001926715,0.04131789],"category_scores_gemma":[0.000883963,0.0001877374,0.000527715,0.0005398389,0.0005679915,0.0006592133,0.0009643275,0.002282169,0.02655514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007460916,"about_ca_system_score_gemma":0.000915189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003958864,"about_ca_topic_score_gemma":0.00101462,"domain_scores_codex":[0.9995932,0.00007984223,0.00003295192,0.00009921471,0.0001348515,0.00005983917],"domain_scores_gemma":[0.9995597,0.00008462917,0.0001043398,0.00003269888,0.00007144183,0.0001471008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001242539,0.0002687982,0.0002931714,0.002415632,0.00008012733,0.001806048,0.0001171718,0.0003085189,0.04315785,0.02298638,0.3063356,0.6209881],"study_design_scores_gemma":[0.0002618702,0.0004354881,0.0004236878,0.0002298569,0.00001814535,0.002427661,0.00001031613,0.00008629208,0.005859119,0.001826453,0.9884007,0.00002034287],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01849175,0.6208825,0.01237484,0.02954658,0.0232755,0.000905108,0.001993346,0.003638269,0.2888922],"genre_scores_gemma":[0.1317619,0.2856575,0.02071556,0.02584687,0.01005457,0.002097409,0.004330075,0.0006085333,0.5189276],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.04131789,"threshold_uncertainty_score":0.1382221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005900815163805081,"score_gpt":0.2427122663161498,"score_spread":0.2368114511523448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}