{"id":"W4200089097","doi":"10.1002/ange.202112288","title":"Accessing Unsymmetrically Linked Heterocycles through Stereoselective Palladium‐Catalyzed Domino Cyclization","year":2021,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Kennarshore","keywords":"Alkyne; Nucleophile; Stereoselectivity; Chemistry; Palladium; Catalysis; Domino; Yield (engineering); Combinatorial chemistry; Cascade reaction; Medicinal chemistry; Organic chemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001876968,0.0003341859,0.0004257997,0.00009289865,0.0002294866,0.0002355717,0.0002793054,0.0003005282,0.002849856],"category_scores_gemma":[0.001174426,0.0003559597,0.0002126513,0.00105876,0.00009851121,0.0004550836,0.0001997378,0.0002861313,0.00005612413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003405323,"about_ca_system_score_gemma":0.0002295616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000403882,"about_ca_topic_score_gemma":0.00002965913,"domain_scores_codex":[0.9977223,0.00005136033,0.0005615891,0.0007368587,0.0005100989,0.0004177753],"domain_scores_gemma":[0.9979433,0.0005257121,0.0002805598,0.0006019399,0.0005000007,0.0001484183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008452077,0.0001647081,0.003097396,0.0001776189,0.0001809882,0.00003839669,0.0004927218,0.00005514593,0.9905558,0.0002076176,0.001605364,0.003339716],"study_design_scores_gemma":[0.001415606,0.000005817656,0.0009420438,0.0000904806,0.0001217754,0.00006168396,0.0002171992,0.000106554,0.9798142,0.001414731,0.01541016,0.0003997996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7235777,0.003598139,0.1072173,0.001145695,0.0008969511,0.0002953583,0.0001742194,0.0008686738,0.1622259],"genre_scores_gemma":[0.9689253,0.0003942145,0.01815127,0.0008831021,0.001117878,0.00007314575,0.002721955,0.0001353907,0.007597749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2453476,"threshold_uncertainty_score":0.9998893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04060922546022926,"score_gpt":0.3081529977677261,"score_spread":0.2675437723074969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}