{"id":"W4200089937","doi":"10.1097/qai.0000000000002880","title":"Brief Report: Nicotine Metabolism Ratio Increases in HIV-Positive Smokers on Effective Antiretroviral Therapy: A Cohort Study","year":2021,"lang":"en","type":"article","venue":"JAIDS Journal of Acquired Immune Deficiency Syndromes","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse; National Institute of Mental Health; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Efavirenz; CYP2A6; Medicine; Confidence interval; Internal medicine; Cotinine; Cohort; Cohort study; Population; Viral load; Retrospective cohort study; CYP2B6; Nicotine; Human immunodeficiency virus (HIV); Antiretroviral therapy; Immunology; CYP3A4; Metabolism; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001673651,0.0003703875,0.0003528293,0.000536863,0.0006159827,0.0008491231,0.0005252816,0.0008295437,0.002133265],"category_scores_gemma":[0.004030135,0.0004504141,0.0007005031,0.0009535604,0.0001839538,0.0005078299,0.0003860327,0.0007182009,0.0003337312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002011023,"about_ca_system_score_gemma":0.0004143521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003363963,"about_ca_topic_score_gemma":0.003240354,"domain_scores_codex":[0.9992048,0.0002245992,0.0001013542,0.0002494411,0.0001577959,0.00006202138],"domain_scores_gemma":[0.9966493,0.0005940215,0.001492881,0.0004691525,0.00042984,0.0003647618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001989418,0.00005804119,0.9977754,0.00002140748,0.000185415,0.00006156361,0.00003388423,0.00001235628,0.0001698155,0.000007733889,0.0002625668,0.001212892],"study_design_scores_gemma":[0.00002886061,0.0001933211,0.9986722,0.000008605163,0.0001703818,0.0003969944,0.000048806,0.0001082146,0.00006405468,0.00001349521,0.0002889875,0.000006085423],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952008,0.0009241609,0.0003088401,0.000149506,0.00007680565,0.00006550992,0.002715448,0.00001443807,0.0005445054],"genre_scores_gemma":[0.9966944,0.0004787606,0.0004284334,0.0001703726,0.0001370963,0.0000539157,0.001518651,0.000008070087,0.0005103252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003363963,"threshold_uncertainty_score":0.00885123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01466251163898242,"score_gpt":0.2898586505926155,"score_spread":0.275196138953633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}