{"id":"W4200092447","doi":"10.3233/kca-210117","title":"Extended Disease Control with Unconventional Cabozantinib Dose Increase in Metastatic Renal Cell Carcinoma","year":2021,"lang":"en","type":"article","venue":"Kidney Cancer","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"National Cancer Institute; Exelixis; University of Texas Southwestern Medical Center; Burroughs Wellcome Fund","keywords":"Cabozantinib; Medicine; Disease; Renal cell carcinoma; Cancer research; Oncology; Internal medicine; Urology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001367077,0.0002899598,0.0004895353,0.000137027,0.00005464002,0.00002689223,0.00007401865,0.00004177627,0.002577856],"category_scores_gemma":[0.0001222527,0.0002252533,0.0001695203,0.0003720657,0.00009317508,0.0000968413,0.00003376465,0.0002226874,0.00004413612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003592216,"about_ca_system_score_gemma":0.004082616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001037985,"about_ca_topic_score_gemma":0.0002288335,"domain_scores_codex":[0.9979641,0.000159904,0.0003549183,0.0005554013,0.0005415254,0.0004240946],"domain_scores_gemma":[0.9980158,0.00007310572,0.0001150541,0.0004490957,0.0002298122,0.001117169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01264307,0.003373244,0.8897125,0.001229479,0.000631755,0.04408985,0.0003442877,0.0002345342,0.03324049,0.0003744967,0.01186211,0.002264265],"study_design_scores_gemma":[0.03000542,0.0003428309,0.9389495,0.0004601667,0.0013194,0.0001876611,0.00009634701,0.0005268139,0.02217947,0.0001317914,0.005434654,0.0003659029],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987016,0.005156265,0.00007175124,0.002955175,0.0001428585,0.0006941695,0.0004300451,0.00003491357,0.003498803],"genre_scores_gemma":[0.9908957,0.00007265891,0.0006598184,0.002776481,0.0001530989,0.0003755958,0.0003431472,0.0000458086,0.004677621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04923711,"threshold_uncertainty_score":0.9983339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01581873338030816,"score_gpt":0.2664854274567906,"score_spread":0.2506666940764825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}