{"id":"W4200095169","doi":"10.1093/ofid/ofab466.836","title":"639. Time to Recurrence of <i>Clostridioides difficile</i> Infection (rCDI) is Rapid Following Completion of Standard of Care Antibiotics: Results from ECOSPOR-III, a Phase 3 Double-Blind, Placebo-Controlled Randomized Trial of SER-109, an Investigational Microbiome Therapeutic","year":2021,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Placebo; Clinical endpoint; Internal medicine; Population; Randomization; Discontinuation; Antibiotics; Clostridium difficile; Randomized controlled trial; Surrogate endpoint; Gastroenterology; Surgery; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001489977,0.0003958585,0.0009207553,0.0001520651,0.0001795049,0.0003842349,0.0002582892,0.0006113473,0.004001977],"category_scores_gemma":[0.001583258,0.0002160155,0.0009140025,0.0001831448,0.0003064811,0.0002857998,0.0001636108,0.001062695,0.0004025142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002364663,"about_ca_system_score_gemma":0.0004965987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004593,"about_ca_topic_score_gemma":0.0009960661,"domain_scores_codex":[0.9994199,0.0003259224,0.0000510292,0.00007522807,0.00004757638,0.00008042718],"domain_scores_gemma":[0.9986421,0.0004633203,0.0004442607,0.00007302306,0.0000926824,0.0002844508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9102786,0.008919965,0.007465671,0.0006946968,0.0008770307,0.00005562712,0.00004881197,0.00025516,0.01255198,0.0000572391,0.001213872,0.05758129],"study_design_scores_gemma":[0.2751757,0.6348655,0.07829025,0.0001495265,0.001822988,0.0001752562,0.00006506327,0.0009625143,0.00682932,0.00009292096,0.001541928,0.00002904356],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956897,0.001744815,0.0002644951,0.0001480084,0.00009681599,0.0004233278,0.0004784554,0.0000317463,0.001122651],"genre_scores_gemma":[0.997027,0.0007001566,0.0004734427,0.0001805577,0.0001137236,0.000335556,0.0004192075,0.00000630575,0.0007441087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004001977,"threshold_uncertainty_score":0.01338792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03046016719986784,"score_gpt":0.3384214320410459,"score_spread":0.307961264841178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}