{"id":"W4200095169","doi":"10.1093/ofid/ofab466.836","title":"639. Time to Recurrence of <i>Clostridioides difficile</i> Infection (rCDI) is Rapid Following Completion of Standard of Care Antibiotics: Results from ECOSPOR-III, a Phase 3 Double-Blind, Placebo-Controlled Randomized Trial of SER-109, an Investigational Microbiome Therapeutic","year":2021,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Placebo; Clinical endpoint; Internal medicine; Population; Randomization; Discontinuation; Antibiotics; Clostridium difficile; Randomized controlled trial; Surrogate endpoint; Gastroenterology; Surgery; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009583839,0.0004270771,0.002904017,0.0004877489,0.0001619455,0.00007846706,0.000313645,0.0002116789,0.000636734],"category_scores_gemma":[0.00122328,0.0003865059,0.001019065,0.001069635,0.0003544186,0.000279584,0.0002591164,0.0002386876,0.00001030857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002362128,"about_ca_system_score_gemma":0.001669926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001594799,"about_ca_topic_score_gemma":0.0001637544,"domain_scores_codex":[0.9952005,0.0006000433,0.002079705,0.0007151802,0.0009850641,0.0004194985],"domain_scores_gemma":[0.9950589,0.001086251,0.001159375,0.0008049512,0.001536507,0.0003540173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8223056,0.003013388,0.001079445,0.0002805175,0.001276105,0.0000106484,0.0005113683,0.0001567312,0.1687233,0.00004780806,0.0004598906,0.002135176],"study_design_scores_gemma":[0.5766662,0.003920788,0.00007563508,0.000673922,0.001060046,0.000004464288,0.000243525,0.0002163834,0.4167533,0.00007808952,0.0001018988,0.0002057412],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854038,0.0009389461,0.0001187791,0.0003143967,0.0002730495,0.006601227,0.00522837,0.00003938751,0.00108206],"genre_scores_gemma":[0.9960016,0.0002804446,0.0001459818,0.00008637326,0.0001097728,0.00007845426,0.003161994,0.00004772807,0.00008763654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.24803,"threshold_uncertainty_score":0.9998587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03046016719986784,"score_gpt":0.3384214320410459,"score_spread":0.307961264841178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}